Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25815809 | 0.89 | HTR6 (0.40) | CHRM5ADRA2CHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL24480842 | 0.88 | KMT2A (0.40) | CHRM5ADRA2CHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL3309077 | 0.84 | CHRM5 (0.39) | CHRM5ADRA2CHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL25820816 | 0.84 | ACHE (0.41) | HPGDKMT2ASMN1; SMN2ACHEHTR6 | |
| SCHEMBL25815386 | 0.84 | SMN1; SMN2 (0.34) | HPGDKMT2ASMN1; SMN2ACHEHTR6 | |
| SCHEMBL24196541 | 0.83 | CHRM5 (0.48) | CHRM5ADRA2CSMN1; SMN2ACHEHTR6 | |
| SCHEMBL24480965 | 0.83 | KMT2A (0.39) | CHRM5ADRA2CKMT2AACHEOPRM1 | |
| SCHEMBL92626 | 0.83 | CHRM5 (0.48) | CHRM5ADRA2CSMN1; SMN2ACHESIGMAR1 | |
| SCHEMBL20873850 | 0.83 | CHRM5 (0.48) | CHRM5ADRA2CSMN1; SMN2ACHESIGMAR1 | |
| SCHEMBL2912326 | 0.83 | CHRM5 (0.48) | CHRM5ADRA2CSMN1; SMN2ACHESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |