SCHEMBL3440600

SCHEMBL3440600

CC(C)(C)[Si](C)(C)Oc1ccc(B(O)O)c(F)c1F

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 2/20 0.33
FEN1 P39748 2/20 0.33
DRD2 P14416 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21751366 0.85 ENPP2 (0.38) ALOX5APFEN1
SCHEMBL15912872 0.79 ALOX5AP (0.38) ALOX5APFEN1
SCHEMBL29950952 0.76 ALOX5AP (0.36) ALOX5APFEN1
SCHEMBL15912887 0.76 FEN1 (0.54) ALOX5APFEN1
SCHEMBL23537729 0.76 ALOX5AP (0.40) ALOX5APFEN1DRD2
SCHEMBL2555302 0.75 DRD2 (0.33) ALOX5APFEN1DRD2
SCHEMBL5981875 0.75 ALOX5AP (0.31) ALOX5APFEN1
SCHEMBL15269311 0.74 ENPP2 (0.52) DRD2
SCHEMBL8162621 0.74 ALOX5AP (0.35) ALOX5APFEN1
SCHEMBL29470875 0.72 ENPP2 (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2065361-B1 Polymerisable compounds MERCK PATENT GMBH (DE) 2014-12-17 EP disclosed
US-7807068-B2 reacting 4-halo-2,6-difluorophenol with protecting group, dehalogenating to form protected phenol ether group, reacting with boronic acid/ester, coupling in presence of catalyst, deblocking, etherifying, esterifying; for optical, electro-optical and electronic use, liquid-crystal media and displays MERCK PATENT GESELLSCHAFT (DE) 2010-10-05 US disclosed
US-20090141215-A1 POLYMERIZABLE COMPOUNDS MERCK PATENT GESELLSCHAFT (DE) 2009-06-04 US disclosed
EP-2065361-A2 Polymerisable compounds Merck Patent GmbH (DE) 2009-06-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090141215-A1 POLYMERIZABLE COMPOUNDS VCL, LCP1, LPXN ALOX5AP 1543/4885FEN1 3872/4885DRD2 3135/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.