Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | GSTA1 | P08263 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | LIG1 | P18858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669181 | 0.90 | HTT (0.55) | LMNAGAAHPGDALDH1A1HTT | |
| SCHEMBL11756485 | 0.83 | MAPT (0.52) | LMNAGAAHPGDGSTA1ALOX15 | |
| 2,2'-Dihydroxybenzphenone SCHEMBL18422 | 0.81 | HPGD (0.67) | LMNAGAAHPGDGSTA1CYP1A2 | |
| 2,2'-Dihydroxybenzphenone SCHEMBL29572496 | 0.81 | HPGD (0.67) | LMNAGAAHPGDGSTA1CYP1A2 | |
| SCHEMBL27205433 | 0.81 | ALDH1A1 (0.54) | GAACYP3A4ALOX15ALDH1A1HTT | |
| SCHEMBL455832 | 0.79 | LIG1 (0.64) | LMNAGAAHPGDGSTA1CYP1A2 | |
| 2,2'-Dihydroxybenzphenone SCHEMBL11145317 | 0.79 | LIG1 (0.64) | LMNAGAAHPGDGSTA1CYP1A2 | |
| 2,2'-Dihydroxybenzphenone SCHEMBL6652370 | 0.79 | LIG1 (0.64) | LMNAGAAHPGDGSTA1CYP1A2 | |
| SCHEMBL8578095 | 0.78 | AKR1C3 (0.55) | GAAHPGDALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3440477 | 0.77 | TSHR (0.63) | LMNAHPGDALOX15ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450374-B2 | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | UNIVERSITY OF DELAWARE (US) | 2013-05-28 | — | — | US | disclosed |
| US-20100331418-A1 | Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal | UNIVERSITY OF DELAWARE | 2010-12-30 | — | — | US | disclosed |
| US-7807713-B2 | Pan-antagonists for the androgen receptor and androgen associated with anti-androgen withdrawal | UNIVERSITY OF DELAWARE (US) | 2010-10-05 | — | — | US | disclosed |
| US-7807713-B2 | Pan-antagonists for the androgen receptor and androgen associated with anti-androgen withdrawal | UNIVERSITY OF DELAWARE (US) | 2010-10-05 | — | — | US | disclosed |
| US-20090270512-A1 | Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-10-29 | — | — | US | disclosed |
| US-20090270512-A1 | Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-10-29 | — | — | US | disclosed |
| US-7550505-B2 | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | UNIVERSITY OF DELAWARE (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550505-B2 | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | UNIVERSITY OF DELAWARE (US) | 2009-06-23 | — | — | US | disclosed |
| US-20080064757-A1 | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-03-13 | — | — | US | disclosed |
| US-20080064757-A1 | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-03-13 | — | — | US | disclosed |
| WO-2008013791-A2 | PAN-ANTAGONISTS FOR THE ANDROGEN RECEPTOR AND ANDROGEN RECEPTOR MUTANTS ASSOCIATED WITH ANTI-ANDROGEN WITHDRAWAL | UNIVERSITY OF DELAWARE (US) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270512-A1 | Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal | AR, NR5A1, SHBG | LMNA 4175/4885GAA 3879/4885HPGD 1777/4885 |
| US-20080064757-A1 | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal | AR, NR5A1, SHBG | LMNA 4175/4885GAA 3879/4885HPGD 1777/4885 |
| US-20100331418-A1 | Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal | AR, NR5A1, SHBG | LMNA 4175/4885GAA 3879/4885HPGD 1777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.