Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.31 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314591 | 0.75 | MEN1 (0.40) | MEN1KMT2APOLBEDNRBEDNRA | |
| SCHEMBL11411069 | 0.68 | POLB (0.40) | MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL4060635 | 0.68 | MEN1 (0.40) | MEN1KMT2AS100A4POLBEDNRB | |
| SCHEMBL1032657 | 0.68 | KMT2A (0.40) | MEN1KMT2APOLBALDH1A1CDC25B | |
| SCHEMBL11052520 | 0.68 | POLB (0.40) | MEN1KMT2AS100A4POLBEDNRB | |
| SCHEMBL9617399 | 0.68 | MEN1 (0.40) | MEN1KMT2AS100A4POLBEDNRB | |
| SCHEMBL11416663 | 0.68 | MEN1 (0.36) | MEN1KMT2APOLBEDNRBEDNRA | |
| SCHEMBL7892212 | 0.67 | ALDH1A1 (0.41) | MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL8011185 | 0.66 | ALDH1A1 (0.46) | MEN1KMT2APOLBEDNRBEDNRA | |
| SCHEMBL10670754 | 0.66 | MEN1 (0.38) | MEN1KMT2APOLBEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807830-B2 | Manufacture of pure hydralazine salts | NAVINTA LLC (US) | 2010-10-05 | — | — | US | disclosed |
| US-20090187018-A1 | temperature-assisted dissolution of hydralazine. HCl in an aqueous solvent ( ethanol, methanol, tetrahydrofuran), treatment of the solution with a clarifying agent selected from chelating agents (EDTA), activated carbon, filtration to remove chelate compounds, cooling to precipitate hydralazine.HCl | NAVINTA LLC (US) | 2009-07-23 | — | — | US | disclosed |
| US-7531653-B2 | Manufacture of pure hydralazine salts | NAVINTA LLC (US) | 2009-05-12 | — | — | US | disclosed |
| US-20070129546-A1 | Manufacture of pure hydralazine salts | NAVINTA LLC | 2007-06-07 | — | — | US | disclosed |