SCHEMBL3440771

SCHEMBL3440771

COc1ccc(C=CC(=O)c2ccc(OCC(O)CN3CCN(c4ccccc4)CC3)cc2)cc1OC

nearest known ligand 0.62

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 3/20 0.62
MAPK1 P28482 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
KDM4E B2RXH2 2/20 0.57
CYP3A4 P08684 1/20 0.57
HPGD P15428 1/20 0.57
CYP2C19 P33261 1/20 0.57
MAPT P10636 6/20 0.56
LMNA P02545 2/20 0.56
KMT2A Q03164 3/20 0.54
MEN1 O00255 2/20 0.54
ATM Q13315 1/20 0.54
ABCB1 P08183 2/20 0.54
ALDH1A1 P00352 1/20 0.53
TNFRSF1A P19438 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30384498 1.00 HTR7 (0.62) HTR7MAPK1L3MBTL1KDM4ECYP3A4
SCHEMBL3440769 1.00 HTR7 (0.62) HTR7MAPK1L3MBTL1KDM4ECYP3A4
SCHEMBL30384562 0.93 HTR7 (0.60) HTR7MAPK1L3MBTL1KDM4ECYP3A4
SCHEMBL13105457 0.93 HTR7 (0.60) HTR7MAPK1L3MBTL1KDM4ECYP3A4
SCHEMBL3440503 0.90 MAPK1 (0.71) HTR7MAPK1L3MBTL1MAPTLMNA
SCHEMBL3440502 0.90 MAPK1 (0.71) HTR7MAPK1L3MBTL1MAPTLMNA
SCHEMBL25192218 0.87 HTR7 (0.70) HTR7MAPK1L3MBTL1MAPTLMNA
SCHEMBL31233271 0.87 HTR7 (0.67) HTR7MAPK1L3MBTL1MAPTLMNA
SCHEMBL25192668 0.87 HTR7 (0.70) HTR7MAPK1L3MBTL1MAPTLMNA
SCHEMBL31233077 0.85 ABCB1 (0.71) HTR7MAPK1L3MBTL1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7807712-B2 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2010-10-05 US claimed
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2006-06-29 US claimed
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
US-7807712-B2 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2010-10-05 US disclosed
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2006-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B HTR7 1804/4885MAPK1 3352/4885L3MBTL1 3658/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 HTR7 2739/4885MAPK1 3412/4885L3MBTL1 2560/4885
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents LIPC, CYP46A1, HMGCR HTR7 2286/4885MAPK1 1830/4885L3MBTL1 2550/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 HTR7 2739/4885MAPK1 3412/4885L3MBTL1 2560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.