Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 5/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3441014 | 0.92 | ALDH1A1 (0.44) | GAAMAPTNPC1RAB9AHPGD | |
| SCHEMBL3441260 | 0.90 | MEN1 (0.44) | GAAMAPTNPC1RAB9AHPGD | |
| SCHEMBL3440827 | 0.88 | NAMPT (0.40) | GAAMAPTNPC1RAB9AHPGD | |
| SCHEMBL3440832 | 0.88 | ALDH1A1 (0.43) | GAAMAPTNPC1RAB9AHPGD | |
| SCHEMBL3441263 | 0.87 | RAB9A (0.41) | GAAMAPTNPC1RAB9AHPGD | |
| SCHEMBL3440836 | 0.86 | ALDH1A1 (0.40) | GAAMAPTNPC1RAB9AHPGD | |
| SCHEMBL3440840 | 0.85 | CCR3 (0.43) | MAPTNPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL3440957 | 0.85 | RAB9A (0.39) | GAAMAPTNPC1RAB9AHPGD | |
| SCHEMBL3441017 | 0.85 | SMN1; SMN2 (0.39) | GAAMAPTNPC1RAB9AHPGD | |
| SCHEMBL3440989 | 0.84 | BRD4 (0.42) | GAAMAPTNPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232272-B2 | Benzimidazoledihydrothiadiazinone derivatives as fructose-1,6-bisphosphatase inhibitors, and pharmaceutical compositions comprising same | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-07-31 | — | — | US | claimed |
| US-20100286129-A1 | NOVEL BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-11 | — | — | US | claimed |
| EP-2229385-A2 | BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Merck Patent GmbH (DE) | 2010-09-22 | — | — | EP | claimed |
| WO-2009062576-A2 | BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | MERCK PATENT GMBH (DE) | 2009-05-22 | — | — | WO | claimed |
| EP-2058308-A1 | Benzimidazoledihydrothiadiazinone derivatives used as fructose-1,6-biphosphatase inhibitors and pharmaceutical compositions containing same. | Merck Sante (FR) | 2009-05-13 | — | — | EP | claimed |
| WO-2023176784-A1 | MULTILAYER STRUCTURE | 三菱ケミカル株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2021256436-A1 | ETHYLENE-VINYL-ALCOHOL-BASED COPOLYMER RESIN COMPOSITION, MULTILAYER STRUCTURAL BODY, AND PACKAGING BODY | 三菱ケミカル株式会社 | 2021-12-23 | — | — | WO | disclosed |
| WO-2019163835-A1 | RUBBER COMPOSITION, TIRE, CONVEYOR BELT, RUBBER CRAWLER, VIBRATION ISOLATION DEVICE, SEISMIC ISOLATION DEVICE, AND HOSE | 株式会社ブリヂストン | 2019-08-29 | — | — | WO | disclosed |
| WO-2019163230-A1 | RUBBER COMPOSITION, TIRE, CONVEYOR BELT, RUBBER CRAWLER, VIBRATION-DAMPING DEVICE, SEISMIC ISOLATOR, AND HOSE | 株式会社ブリヂストン | 2019-08-29 | — | — | WO | disclosed |
| WO-2019142501-A1 | RUBBER COMPOSITION, TIRE, CONVEYOR BELT, RUBBER CRAWLER, VIBRATION-DAMPING DEVICE, SEISMIC ISOLATOR, AND HOSE | 株式会社ブリヂストン | 2019-07-25 | — | — | WO | disclosed |
| WO-2019078083-A1 | MULTI-COPOLYMER, RUBBER COMPOSITION, CROSS-LINKED RUBBER COMPOSITION, RUBBER ARTICLE, AND TIRE | 株式会社ブリヂストン | 2019-04-25 | — | — | WO | disclosed |
| EP-1682324-B1 | METHOD AND PLANT FOR THE INTRODUCTION OF A LIQUID INTO A MOLTEN MASS UNDER PRESSURE | PRYSMIAN SPA (IT) | 2016-08-10 | — | — | EP | disclosed |
| US-20070248748-A1 | Method and Plant for the Introduction of a Liquid Into a Molten Mass Under Pressure | PRYSMIAN CAVI E SISTEMI ENERGIA S.R.L. (IT) | 2007-10-25 | — | — | US | disclosed |
| EP-1682324-A1 | METHOD AND PLANT FOR THE INTRODUCTION OF A LIQUID INTO A MOLTEN MASS UNDER PRESSURE | Prysmian Cavi e Sistemi Energia S.r.l. (IT) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042226-A1 | METHOD AND PLANT FOR THE INTRODUCTION OF A LIQUID INTO A MOLTEN MASS UNDER PRESSURE | PRYSMIAN CAVI E SISTEMI ENERGIA S.R.L. (IT) | 2005-05-12 | — | — | WO | disclosed |
| US-20030173104-A1 | Process for producing a cable, particularly for electrical power transmission or distribution, and cable produced therefrom | PIRELLI CAVI E SISTEMI S.P.A. (IT) | 2003-09-18 | — | — | US | disclosed |
| EP-1307890-A1 | PROCESS FOR PRODUCING A CABLE, PARTICULARLY FOR ELECTRICAL POWER TRANSMISSION OR DISTRIBUTION, AND CABLE PRODUCED THEREFROM | PIRELLI S.p.A. (IT) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002013204-A1 | PROCESS FOR PRODUCING A CABLE, PARTICULARLY FOR ELECTRICAL POWER TRANSMISSION OR DISTRIBUTION, AND CABLE PRODUCED THEREFROM | PIRELLI CAVI E SISTEMI S.P.A. (IT) | 2002-02-14 | — | — | WO | disclosed |
| EP-1042763-A1 | ELECTRICAL CABLE HAVING A SEMICONDUCTIVE WATER-BLOCKING EXPANDED LAYER | PIRELLI S.p.A. (IT) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033070-A1 | ELECTRICAL CABLE HAVING A SEMICONDUCTIVE WATER-BLOCKING EXPANDED LAYER | PIRELLI CAVI E SISTEMI S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286129-A1 | NOVEL BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | FBP1, ALDOA, GCK | GAA 58/4885MAPT 2599/4885NPC1 2824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.