Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.52 |
| ▸ | ME2 | P23368 | 1/20 | 0.48 |
| ▸ | ME1 | P48163 | 1/20 | 0.48 |
| ▸ | ME3 | Q16798 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | EDNRB | P24530 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3442740 | 0.90 | USP2 (0.52) | DGAT1EDNRBEDNRAFAAHMEN1 | |
| SCHEMBL3269073 | 0.87 | FAAH (0.42) | DGAT1HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL3442445 | 0.87 | DGAT1 (0.49) | DGAT1TRPV1EDNRBEDNRAFAAH | |
| SCHEMBL3268557 | 0.84 | FAAH (0.46) | DGAT1TRPV1FAAHMEN1POLB | |
| SCHEMBL3442676 | 0.83 | KDM4E (0.48) | DGAT1TRPV1FAAHPOLBMAPT | |
| SCHEMBL3268330 | 0.82 | FAAH (0.52) | DGAT1TRPV1FAAHMAPT | |
| SCHEMBL3269594 | 0.80 | FAAH (0.48) | DGAT1TRPV1FAAHMAPTUSP2 | |
| SCHEMBL3268193 | 0.80 | FAAH (0.50) | TRPV1FAAH | |
| SCHEMBL3765680 | 0.80 | FAAH (0.73) | FAAH | |
| SCHEMBL3778588 | 0.80 | AR (0.52) | FAAHMEN1KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812025-B2 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-10-12 | — | — | US | claimed |
| US-20090048263-A1 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-02-19 | — | — | US | claimed |
| EP-1923388-A1 | BRAIN/NEURONAL CELL-PROTECTING AGENT, AND THERAPEUTIC AGENT FOR SLEEP DISORDER | Takeda Pharmaceutical Company Limited (JP) | 2008-05-21 | — | — | EP | claimed |
| US-7812025-B2 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-10-12 | — | — | US | disclosed |
| US-20090048263-A1 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-02-19 | — | — | US | disclosed |
| EP-1923388-A1 | BRAIN/NEURONAL CELL-PROTECTING AGENT, AND THERAPEUTIC AGENT FOR SLEEP DISORDER | Takeda Pharmaceutical Company Limited (JP) | 2008-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048263-A1 | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder | HCRTR1, HCRTR2, MTNR1A | DGAT1 2871/4885ME2 1061/4885ME1 3404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.