SCHEMBL344381

SCHEMBL344381

COC(=O)C(COC(C)(C)C)NC(=O)OCc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CTSK P43235 9/20 0.63
CTSS P25774 6/20 0.63
CTSL P07711 5/20 0.63
KYNU Q16719 1/20 0.58
ALDH1A1 P00352 1/20 0.56
ALOX15 P16050 1/20 0.56
SYK P43405 1/20 0.55
CTSB P07858 3/20 0.54
TRPM8 Q7Z2W7 1/20 0.50
CAPN1 P07384 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL344382 1.00 CTSK (0.63) CTSKCTSSCTSLKYNUALDH1A1
SCHEMBL29401640 1.00 CTSK (0.63) CTSKCTSSCTSLKYNUALDH1A1
SCHEMBL3819501 0.95 CTSK (0.64) CTSKCTSSCTSLKYNUALDH1A1
SCHEMBL31276793 0.95 CTSK (0.64) CTSKCTSSCTSLKYNUALDH1A1
SCHEMBL3818440 0.91 CTSS (0.63) CTSKCTSSCTSLKYNUALDH1A1
SCHEMBL1410812 0.91 CTSK (0.61) CTSKCTSSCTSLKYNUALDH1A1
SCHEMBL607263 0.91 CTSK (0.61) CTSKCTSSCTSLKYNUALDH1A1
SCHEMBL1409909 0.91 CTSK (0.61) CTSKCTSSCTSLKYNUALDH1A1
SCHEMBL14479032 0.90 CTSK (0.58) CTSKCTSSCTSLKYNUALDH1A1
SCHEMBL1409906 0.90 CTSK (0.60) CTSKCTSSCTSLKYNUALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109928971-B Aryl substituted aminotetrahydropyrans and uses thereof 广东东阳光药业股份有限公司 2024-01-16 CN disclosed
EP-2669266-B1 Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate DONG A ST CO LTD (KR) 2016-02-24 EP disclosed
WO-2015042397-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES BIOMARIN PHARMACEUTICAL INC. (US) 2015-03-26 WO disclosed
EP-2669266-A1 Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate Dong-A Pharmaceutical Co., Ltd. (KR) 2013-12-04 EP disclosed
US-8598347-B2 Method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate DONG-A PHARMACEUTICAL. CO., LTD (KR) 2013-12-03 US disclosed
EP-2415754-A2 IMPROVED METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE Dong-A Pharmaceutical Co., Ltd. (KR) 2012-02-08 EP disclosed
US-20120016126-A1 METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE DONG-A PHARMACEUTICAL. CO., LTD (KR) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120016126-A1 METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE DPP4, DPP3, DPP7 CTSK 367/4885CTSS 584/4885CTSL 113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.