Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3443905 | 0.87 | HTT (0.43) | SLC6A2SLC6A3SLC6A4MC4RHTT | |
| SCHEMBL3445070 | 0.87 | MEN1 (0.51) | MEN1KMT2AKCNH2TSHR | |
| SCHEMBL3444378 | 0.86 | MAPT (0.47) | SLC6A2KCNH2ALDH1A1 | |
| SCHEMBL3445072 | 0.85 | SLC6A2 (0.51) | SLC6A2MC4RMEN1KMT2ADRD2 | |
| SCHEMBL3444876 | 0.85 | SLC6A2 (0.46) | SLC6A2MC4RALDH1A1 | |
| SCHEMBL3444990 | 0.85 | HTT (0.56) | SLC6A2MC4RHTTMEN1KMT2A | |
| SCHEMBL3444359 | 0.84 | GAA (0.50) | MC4RMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL3444821 | 0.83 | HRH4 (0.49) | SLC6A2MEN1KMT2ADRD2KCNH2 | |
| SCHEMBL3444777 | 0.83 | HTT (0.43) | SLC6A2SLC6A3SLC6A4MC4RHTT | |
| SCHEMBL3445355 | 0.81 | MEN1 (0.56) | MEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390812-B2 | N, N'-disubstituted piperazine compounds and their use as analgesics | GRUENENTHAL GMBH (DE) | 2008-06-24 | — | — | US | claimed |
| EP-1496904-B1 | USE OF PHARMACEUTICALS CONTAINING N, N'-DISUBSTITUTED PIPERAZINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2007-08-15 | — | — | EP | claimed |
| EP-1492781-B1 | N,N'-DISUBSTITUTED PIPERAZINE COMPOUNDS AND THE USE OF THE SAME AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2006-03-08 | — | — | EP | claimed |
| US-20050038034-A1 | Pharmaceutical formulations comprising N,N'-disubstituted piperazine compounds | GRUNENTHAL GMBH (DE) | 2005-02-17 | — | — | US | claimed |
| US-20050026926-A1 | N, N'-disubstituted piperazine compounds and their use as analgesics | GRUENENTHAL GMBH (DE) | 2005-02-03 | — | — | US | claimed |
| EP-1496904-A1 | PHARMACEUTICAL CONTAINING N, N'-DISUBSTITUTED PIPERAZINE COMPOUNDS | Grünenthal GmbH (DE) | 2005-01-19 | — | — | EP | claimed |
| WO-2003051369-A1 | PHARMACEUTICAL CONTAINING N, N'-DISUBSTITUTED PIPERAZINE COMPOUNDS | Grünenthal GmbH (DE) | 2003-06-26 | — | — | WO | claimed |
| US-7816358-B2 | Pharmaceutical formulations comprising N,N′-disubstituted piperazine compounds | GRUENENTHAL GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| US-7390812-B2 | N, N'-disubstituted piperazine compounds and their use as analgesics | GRUENENTHAL GMBH (DE) | 2008-06-24 | — | — | US | disclosed |
| EP-1496904-B1 | USE OF PHARMACEUTICALS CONTAINING N, N'-DISUBSTITUTED PIPERAZINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2007-08-15 | — | — | EP | disclosed |
| EP-1492781-B1 | N,N'-DISUBSTITUTED PIPERAZINE COMPOUNDS AND THE USE OF THE SAME AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2006-03-08 | — | — | EP | disclosed |
| US-20050038034-A1 | Pharmaceutical formulations comprising N,N'-disubstituted piperazine compounds | GRUNENTHAL GMBH (DE) | 2005-02-17 | — | — | US | disclosed |
| US-20050026926-A1 | N, N'-disubstituted piperazine compounds and their use as analgesics | GRUENENTHAL GMBH (DE) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026926-A1 | N, N'-disubstituted piperazine compounds and their use as analgesics | OPRL1, OPRK1, OPRM1 | SLC6A2 308/4885SLC6A3 762/4885SLC6A4 292/4885 |
| US-20050038034-A1 | Pharmaceutical formulations comprising N,N'-disubstituted piperazine compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NNT, AANAT | SLC6A2 96/4885SLC6A3 498/4885SLC6A4 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.