SCHEMBL344492

SCHEMBL344492

O=C(O)c1c(-c2ccccc2)cccc1C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.49
▸ HPGD P15428 1/20 0.49
▸ FOLH1 Q04609 1/20 0.49
▸ LTB4R Q15722 1/20 0.48
▸ LTB4R2 Q9NPC1 1/20 0.48
▸ FABP4 P15090 1/20 0.47
▸ HNF4A P41235 1/20 0.44
▸ FFAR4 Q5NUL3 1/20 0.44
▸ KMO O15229 2/20 0.44
▸ SLC13A5 Q86YT5 1/20 0.42
▸ PPARG P37231 1/20 0.42
▸ PPARA Q07869 1/20 0.42
▸ TAS2R14 Q9NYV8 2/20 0.41
▸ HSD11B1 P28845 1/20 0.41
▸ SCN9A Q15858 1/20 0.40
▸ HDAC6 Q9UBN7 1/20 0.40
▸ PLK1 P53350 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23908702 0.91 ALDH1A1 (0.51) ALDH1A1HPGDLTB4RLTB4R2FABP4
SCHEMBL6677946 0.86 BCAT2 (0.49) ALDH1A1HPGDFOLH1FABP4FFAR4
SCHEMBL6584244 0.86 ALDH1A1 (0.43) ALDH1A1HPGDFOLH1LTB4RLTB4R2
SCHEMBL11459853 0.86 NR1H2 (0.49) ALDH1A1HPGDFABP4FFAR4PPARG
SCHEMBL29978674 0.86 BCAT2 (0.49) ALDH1A1HPGDFOLH1FABP4FFAR4
SCHEMBL28636307 0.86 ALDH1A1 (0.45) ALDH1A1HPGDFOLH1LTB4RLTB4R2
SCHEMBL504216 0.82 CA12 (0.46) ALDH1A1HPGDFABP4KMOTAS2R14
SCHEMBL593127 0.80 FOLH1 (0.61) ALDH1A1HPGDFOLH1FABP4HNF4A
SCHEMBL29702020 0.79 ALDH1A1 (0.43) ALDH1A1HPGDFOLH1FABP4FFAR4
SCHEMBL16394743 0.78 ALDH1A1 (0.42) ALDH1A1HPGDKMOTAS2R14PLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240389450-A1 LIGHT EMITTING ELEMENT, PRODUCTION METHOD FOR LIGHT EMITTING ELEMENT, DISPLAY DEVICE, AND PRODUCTION METHOD FOR DISPLAY DEVICE Sharp Display Technology Corporation (JP) 2024-11-21 — — US claimed
WO-2023079616-A1 LIGHT EMITTING ELEMENT, PRODUCTION METHOD FOR LIGHT EMITTING ELEMENT, DISPLAY DEVICE, AND PRODUCTION METHOD FOR DISPLAY DEVICE シャープディスプレイテクノロジー株式会社 2023-05-11 — — WO claimed
US-20240389450-A1 LIGHT EMITTING ELEMENT, PRODUCTION METHOD FOR LIGHT EMITTING ELEMENT, DISPLAY DEVICE, AND PRODUCTION METHOD FOR DISPLAY DEVICE Sharp Display Technology Corporation (JP) 2024-11-21 — — US disclosed
WO-2023079616-A1 LIGHT EMITTING ELEMENT, PRODUCTION METHOD FOR LIGHT EMITTING ELEMENT, DISPLAY DEVICE, AND PRODUCTION METHOD FOR DISPLAY DEVICE シャープディスプレイテクノロジー株式会社 2023-05-11 — — WO disclosed
EP-2470498-A1 CARBOCYCLIC GLYT1 RECEPTOR ANTAGONISTS F. Hoffmann-La Roche AG (CH) 2012-07-04 — — EP disclosed
US-20120016152-A1 Process for the preparation of 4`-haloalkylbiphenyl-2-carboxylic acids SALTIGO GMBH (DE) 2012-01-19 — — US disclosed
EP-2391603-A1 AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS F. Hoffmann-La Roche AG (CH) 2011-12-07 — — EP disclosed
WO-2011023667-A1 CARBOCYCLIC GLYT1 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2011-03-03 — — WO disclosed
WO-2010086251-A1 AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2010-08-05 — — WO disclosed
EP-2094643-A2 N-((3-BENZYL)-2,2-(BIS-PHENYL)-PROPAN-1-AMINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES Brystol-Myers Squibb Company (US) 2009-09-02 — — EP disclosed
EP-2010170-A2 USE OF BIARYLCARBOXAMIDES IN THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS Novartis AG (CH) 2009-01-07 — — EP disclosed
EP-1326835-A1 BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-07-16 — — EP disclosed
EP-1317431-A2 POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 2003-06-11 — — EP disclosed
WO-2002090347-A1 AMIDE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-11-14 — — WO disclosed
WO-2002028835-A1 BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-04-11 — — WO disclosed
WO-2002020501-A2 POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 2002-03-14 — — WO disclosed
US-20010034459-A1 Process for preparing 4'-trifluoromethyl-2-methylbiphenyl and 4'-trifluoromethyl-biphenyl-2-carboxylic acid from o-tolylmetallates MEUDT ANDREAS (DE) 2001-10-25 — — US disclosed
EP-0832069-A1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER INC. (US) 1998-04-01 — — EP disclosed
WO-1996040640-A1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER INC. (US) 1996-12-19 — — WO disclosed
WO-1996022295-A9 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS — 1996-11-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010034459-A1 Process for preparing 4'-trifluoromethyl-2-methylbiphenyl and 4'-trifluoromethyl-biphenyl-2-carboxylic acid from o-tolylmetallates ZC3HAV1L, ZRANB2, ZFP3 ALDH1A1 1678/4885HPGD 4158/4885FOLH1 4286/4885
US-20120016152-A1 Process for the preparation of 4`-haloalkylbiphenyl-2-carboxylic acids CYP4B1, HACL2, UGT1A4 ALDH1A1 110/4885HPGD 1495/4885FOLH1 1070/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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