Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.57 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.57 |
| ▸ | CCR4 | P51679 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977236 | 0.83 | ALDH1A1 (0.61) | HCRTR1HCRTR2CCR4LMNAHPGD | |
| SCHEMBL2977241 | 0.83 | ALDH1A1 (0.61) | HCRTR1HCRTR2CCR4LMNAHPGD | |
| SCHEMBL8318861 | 0.81 | HCRTR1 (0.67) | HCRTR1HCRTR2CCR4LMNAHPGD | |
| SCHEMBL1771231 | 0.80 | HCRTR1 (0.66) | HCRTR1HCRTR2CCR4LMNAHPGD | |
| SCHEMBL1771060 | 0.80 | HCRTR1 (0.66) | HCRTR1HCRTR2CCR4LMNAHPGD | |
| SCHEMBL2100435 | 0.79 | HCRTR1 (0.65) | HCRTR1HCRTR2CCR4LMNAHPGD | |
| SCHEMBL2100430 | 0.79 | HCRTR1 (0.65) | HCRTR1HCRTR2CCR4LMNAHPGD | |
| SCHEMBL30919357 | 0.79 | HCRTR1 (0.65) | HCRTR1HCRTR2CCR4LMNAHPGD | |
| SCHEMBL1770564 | 0.79 | MMP1 (0.66) | HCRTR1HCRTR2CCR4LMNAHPGD | |
| SCHEMBL1770402 | 0.79 | MMP1 (0.66) | HCRTR1HCRTR2CCR4LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260043-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal Gmbh (DE) | 2010-12-15 | — | — | EP | claimed |
| WO-2009124746-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-15 | — | — | WO | claimed |