Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRND | Q07001 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406247 | 0.82 | CHRNB2 (0.67) | CHRNB2CHRNB4CHRNA3CHRNA4TRPV4 | |
| SCHEMBL3446553 | 0.81 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2C | |
| Hydrochloric Acid SCHEMBL4685759 | 0.81 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4TRPV4 | |
| SCHEMBL3446487 | 0.80 | CHRNB2 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2C | |
| SCHEMBL3446448 | 0.78 | CHRNA1 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2C | |
| SCHEMBL5685567 | 0.72 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5685948 | 0.71 | CHRNB2 (0.56) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6651303 | 0.70 | TRPV4 (0.71) | TRPV4ALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL24984208 | 0.69 | TRPV4 (0.48) | CHRNB2CHRNB4CHRNA3CHRNA4TRPV4 | |
| SCHEMBL30918534 | 0.69 | TRPV4 (0.48) | CHRNB2CHRNB4CHRNA3CHRNA4TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816356-B2 | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands | YOHANNES DANIEL | 2010-10-19 | — | — | US | disclosed |
| US-20050182063-A1 | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands | YOHANNES DANIEL (US) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182063-A1 | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands | OPRL1, OPRK1, CHRNB4 | CHRNB2 7/4885CHRNB4 3/4885CHRNA3 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.