Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.35 |
| ▸ | STAMBP | O95630 | 2/20 | 0.35 |
| ▸ | COPS5 | Q92905 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 3/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15427587 | 0.91 | PARP1 (0.43) | PARP1RAB9APSMD14STAMBPCOPS5 | |
| SCHEMBL367739 | 0.88 | PARP1 (0.42) | PARP1RAB9APSMD14STAMBPCOPS5 | |
| SCHEMBL344300 | 0.82 | S1PR1 (0.38) | RAB9AKMT2ATAAR1 | |
| SCHEMBL344103 | 0.73 | PARP1 (0.57) | PARP1PSMD14MEN1KMT2ATRPV1 | |
| SCHEMBL19155527 | 0.73 | PARP1 (0.40) | PARP1KMT2A | |
| SCHEMBL15427585 | 0.73 | S1PR1 (0.40) | RAB9A | |
| SCHEMBL10031662 | 0.72 | RAB9A (0.39) | RAB9ANPC1TRPV1 | |
| SCHEMBL345378 | 0.72 | THRB (0.43) | PARP1MEN1NPC1KMT2ATRPV1 | |
| SCHEMBL344417 | 0.70 | PARP1 (0.58) | PARP1MEN1KMT2A | |
| SCHEMBL345197 | 0.70 | PARP1 (0.55) | PARP1PSMD14TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9714238-B2 | Therapeutic agents for ocular hypertension | ALLERGAN, INC. (US) | 2017-07-25 | — | — | US | disclosed |
| US-20160340347-A9 | THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION | ALLERGAN, INC. (US) | 2016-11-24 | — | — | US | disclosed |
| US-20150175586-A1 | THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION | ALLERGAN, INC. (US) | 2015-06-25 | — | — | US | disclosed |
| US-8633220-B2 | Therapeutic agents for ocular hypertension | ALLERGAN, INC. (US) | 2014-01-21 | — | — | US | disclosed |
| US-20120015978-A1 | THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION | ALLERGAN, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175586-A1 | THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION | PTGIR, NHERF1, PTGS1 | PARP1 1380/4885RAB9A 1818/4885PSMD14 3881/4885 |
| US-20160340347-A9 | THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION | PTGIR, NHERF1, PTGS1 | PARP1 1380/4885RAB9A 1818/4885PSMD14 3881/4885 |
| US-20120015978-A1 | THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION | PTGIR, NHERF1, PTGS1 | PARP1 1380/4885RAB9A 1818/4885PSMD14 3881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.