SCHEMBL344638

SCHEMBL344638

O=C(O)/C=C/c1cc(O)ccc1O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.64
MAPT P10636 4/20 0.64
KDM4E B2RXH2 4/20 0.64
HSD17B10 Q99714 3/20 0.64
MEN1 O00255 2/20 0.64
CYP2C9 P11712 2/20 0.64
HPGD P15428 2/20 0.64
KMT2A Q03164 2/20 0.64
TP53 P04637 1/20 0.64
CYP1A2 P05177 1/20 0.64
ALOX15 P16050 1/20 0.64
CYP2C19 P33261 1/20 0.64
MIF P14174 1/20 0.62
SNCA P37840 1/20 0.62
GAA P10253 4/20 0.61
MGAM O43451 2/20 0.61
SI P14410 2/20 0.61
MGAM2 Q2M2H8 2/20 0.61
CA1 P00915 3/20 0.60
CA2 P00918 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29763068 1.00 ALDH1A1 (0.64) ALDH1A1MAPTKDM4EHSD17B10MEN1
SCHEMBL344639 1.00 ALDH1A1 (0.64) ALDH1A1MAPTKDM4EHSD17B10MEN1
SCHEMBL29065213 0.93 CHRNA7 (0.61) ALDH1A1MAPTKDM4EHSD17B10MEN1
SCHEMBL29065212 0.93 CHRNA7 (0.61) ALDH1A1MAPTKDM4EHSD17B10MEN1
SCHEMBL344123 0.86 ALDH1A1 (0.61) ALDH1A1MAPTKDM4EHSD17B10MEN1
SCHEMBL30468745 0.85 PELI1 (0.58) ALDH1A1MAPTKDM4EHSD17B10MEN1
SCHEMBL89187 0.84 MIF (0.68) MIFGAAMGAMSIMGAM2
SCHEMBL471946 0.84 MIF (0.68) MIFGAAMGAMSIMGAM2
SCHEMBL28140874 0.84 MIF (0.68) MIFGAAMGAMSIMGAM2
SCHEMBL28391865 0.84 MIF (0.68) MIFGAAMGAMSIMGAM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3423429-B1 MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY UNIV DE MONCTON (CA) 2023-07-12 EP claimed
EP-4101870-A1 POLYMER COMPOUND, METHOD FOR PRODUCING POLYMER COMPOUND, ADHESIVE COMPOSITION, CURED PRODUCT, METHOD FOR PRODUCING ADHESIVE COMPOSITION, AND METHOD FOR ADJUSTING ADHESIVE STRENGTH National Institute for Materials Science (JP) 2022-12-14 EP claimed
EP-3647429-A1 METHOD FOR THE ENZYMATIC PRODUCTION OF PHENOLIC COMPOUNDS Clariant International Ltd (CH) 2020-05-06 EP claimed
US-10434076-B2 Use of 2,5-dihydroxybenzene derivatives for treating dermatitis AmDerma Pharmaceuticals, LLC (US) 2019-10-08 US claimed
US-20190192473-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea AmDerma Pharmaceuticals, LLC 2019-06-27 US claimed
US-10278941-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of glioma AmDerma Pharmaceuticals, LLC (US) 2019-05-07 US claimed
US-20180036265-A1 Use of 2,5-Dihydroxybenzene Derivatives for Treating Dermatitis ACTION MEDICINES, S.L. (ES) 2018-02-08 US claimed
US-20180028484-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea AmDerma Pharmaceuticals, LLC 2018-02-01 US claimed
US-9597303-B2 Use of 2,5-dihydroxybenzene derivatives for treating dermatitis AmDerma Pharmaceuticals, LLC (US) 2017-03-21 US claimed
US-9592216-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of rosacea AmDerma Pharmaceuticals, LLC (US) 2017-03-14 US claimed
WO-2008020039-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020027-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR THE TREATMENT OF SKIN CANCER ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020030-A1 2,5-DIHYDROXYBENZENE COMPOUNDS FOR THE TREATMENT OF PSORIASIS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020028-A1 2,5 DIHYDROXYBENZENE COMPOUNDS FOR THE TREATMENT OF ROSACEA ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020031-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ANGIOGENIC DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020037-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING OBESITY, HIRSUTISM, HYPERTRICOSIS AND VIRAL WARTS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020034-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF HEMANGIOMAS OR HEMANGIOBLASTOMAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020033-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ARTHRITIS AND PAIN ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020032-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF OCULAR DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020042-A1 USE OF 2, 5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTIVE DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190192473-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea CYP8B1, CYP1B1, CYP26B1 ALDH1A1 15/4885MAPT 2619/4885KDM4E 2246/4885
US-10434076-B2 Use of 2,5-dihydroxybenzene derivatives for treating dermatitis CYP24A1, CYP8B1, CYP26B1 ALDH1A1 79/4885MAPT 2332/4885KDM4E 1185/4885
US-20180036265-A1 Use of 2,5-Dihydroxybenzene Derivatives for Treating Dermatitis CYP24A1, CYP8B1, CYP26B1 ALDH1A1 79/4885MAPT 2332/4885KDM4E 1185/4885
US-20180028484-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea CYP8B1, CYP1B1, CYP26B1 ALDH1A1 15/4885MAPT 2619/4885KDM4E 2246/4885
US-10278941-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of glioma ALDH1A2, IDH3A, IDH3B ALDH1A1 7/4885MAPT 1843/4885KDM4E 1649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.