Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenyramidol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.88 |
| ▸ | FDPS | P14324 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FABP1 | P07148 | 1/20 | 0.46 |
| ▸ | FABP6 | P51161 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 5/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenyramidol SCHEMBL29500950 | 0.94 | CYP2D6 (1.00) | CYP2D6FDPSKDM4EL3MBTL1FABP1 | |
| Phenyramidol SCHEMBL21963 | 0.94 | CYP2D6 (1.00) | CYP2D6FDPSKDM4EL3MBTL1FABP1 | |
| Phenyramidol SCHEMBL13310227 | 0.94 | CYP2D6 (1.00) | CYP2D6FDPSKDM4EL3MBTL1FABP1 | |
| Phenyramidol SCHEMBL13310219 | 0.94 | CYP2D6 (1.00) | CYP2D6FDPSKDM4EL3MBTL1FABP1 | |
| Phenyramidol SCHEMBL20769334 | 0.92 | CYP2D6 (0.97) | CYP2D6FDPSKDM4EL3MBTL1FABP1 | |
| Phenyramidol SCHEMBL29375712 | 0.92 | CYP2D6 (0.97) | CYP2D6FDPSKDM4EL3MBTL1FABP1 | |
| Phenyramidol SCHEMBL121004 | 0.92 | CYP2D6 (0.97) | CYP2D6FDPSKDM4EL3MBTL1FABP1 | |
| Phenyramidol SCHEMBL22718457 | 0.84 | CYP2D6 (0.71) | CYP2D6FDPSKDM4EGAAPOLB | |
| SCHEMBL9566716 | 0.82 | CYP2D6 (0.77) | CYP2D6FDPSKDM4EGAAPOLB | |
| Phenyramidol SCHEMBL3689817 | 0.80 | CYP2D6 (0.67) | CYP2D6FDPSKDM4EGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027092-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | FERMENTA BIOTECH (UK) LIMITED (GB) | 2009-02-25 | — | — | EP | claimed |
| WO-2007135463-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | FERMENTA BIOTECH (UK) LIMITED (GB) | 2007-11-29 | — | — | WO | claimed |
| US-20130143932-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | FERMENTA BIOTECH (UK) LIMITED (GB) | 2013-06-06 | — | — | US | disclosed |
| US-8389551-B2 | Optical enantiomers of phenyramidol and process for chiral synthesis | FERMENTA BIOTECH (UK) LIMITED (GB) | 2013-03-05 | — | — | US | disclosed |
| US-20100144799-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | FERMENTA BIOTECH (UK) LIMITED (GB) | 2010-06-10 | — | — | US | disclosed |
| US-20090182016-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | FERMENTA BIOTECH (UK) LIMITED (GB) | 2009-07-16 | — | — | US | disclosed |
| EP-2027092-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | FERMENTA BIOTECH (UK) LIMITED (GB) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007135463-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | FERMENTA BIOTECH (UK) LIMITED (GB) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182016-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | QDPR, DYRK4, DYRK3 | CYP2D6 5/4885FDPS 401/4885KDM4E 3870/4885 |
| US-20100144799-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | QDPR, CYP3A4, PPOX | CYP2D6 4/4885FDPS 401/4885KDM4E 3510/4885 |
| US-20130143932-A1 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS | QDPR, CYP3A4, PPOX | CYP2D6 4/4885FDPS 401/4885KDM4E 3510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.