Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA4 | P22748 | 3/20 | 0.56 |
| ▸ | CA6 | P23280 | 3/20 | 0.56 |
| ▸ | CA5A | P35218 | 3/20 | 0.56 |
| ▸ | CA7 | P43166 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 3/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.56 |
| ▸ | F13A1 | P00488 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | THPO | P40225 | 2/20 | 0.56 |
| ▸ | CA3 | P07451 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14519033 | 1.00 | CA12 (0.56) | CA12CA2CA4CA6CA5A | |
| SCHEMBL5810196 | 1.00 | CA12 (0.56) | CA12CA2CA4CA6CA5A | |
| SCHEMBL14163247 | 0.98 | CA12 (0.54) | CA12CA2CA4CA6CA5A | |
| SCHEMBL12227390 | 0.98 | CA12 (0.54) | CA12CA2CA4CA6CA5A | |
| SCHEMBL14360554 | 0.95 | CA12 (0.59) | CA12CA2CA4CA6CA5A | |
| SCHEMBL343049 | 0.95 | CA12 (0.59) | CA12CA2CA4CA6CA5A | |
| SCHEMBL5565820 | 0.93 | CA12 (0.56) | CA12CA2CA4CA6CA5A | |
| SCHEMBL6030226 | 0.93 | CA12 (0.56) | CA12CA2CA4CA6CA5A | |
| SCHEMBL6030318 | 0.93 | CA12 (0.56) | CA12CA2CA4CA6CA5A | |
| SCHEMBL5196477 | 0.93 | CA12 (0.55) | CA12CA2CA4CA6CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202280-B2 | Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration | RAESAENEN TIINA-LIISA | 2007-04-10 | — | — | US | claimed |
| EP-1049444-B1 | REDUCTION OF HAIR GROWTH | GILLETTE CO (US) | 2004-03-24 | — | — | EP | claimed |
| EP-1049444-A1 | REDUCTION OF HAIR GROWTH | THE GILLETTE COMPANY (US) | 2000-11-08 | — | — | EP | claimed |
| US-6060471-A | Reduction of hair growth | VLSI TECHNOLOGY, INC. | 2000-05-09 | — | — | US | claimed |
| WO-1999037277-A1 | REDUCTION OF HAIR GROWTH | THE GILLETTE COMPANY (US) | 1999-07-29 | — | — | WO | claimed |
| CN-108135933-B | Motile sperm domain containing protein 2 and cancer | 脉管生物生长有限公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-107921084-B | Motile sperm domain containing protein 2 and inflammation | 脉管生物生长有限公司 | 2022-04-29 | — | — | CN | disclosed |
| US-20210030703-A1 | USE OF CALORIC RESTRICTION MIMETICS FOR POTENTIATING CHEMO-IMMUNOTHERAPY FOR THE TREATMENT OF CANCERS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-02-04 | — | — | US | disclosed |
| EP-3765085-A1 | USE OF CALORIC RESTRICTION MIMETICS FOR POTENTIATING CHEMO-IMMUNOTHERAPY FOR THE TREATMENT OF CANCERS | Université de Paris (FR) | 2021-01-20 | — | — | EP | disclosed |
| CN-112218658-A | Use of caloric restriction mimetics for enhancing chemoimmunotherapy for cancer treatment | 国家健康科学研究所 | 2021-01-12 | — | — | CN | disclosed |
| US-10617656-B2 | Methods of increasing the cytotoxicity of chemotherapeutic agents with multisubstrate inhibitors of histone, protein-Lys, polyamine acetylation, and polyamine metabolism | VANDERBILT UNIVERSITY (US) | 2020-04-14 | — | — | US | disclosed |
| WO-2019175113-A1 | USE OF CALORIC RESTRICTION MIMETICS FOR POTENTIATING CHEMO-IMMUNOTHERAPY FOR THE TREATMENT OF CANCERS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2019-09-19 | — | — | WO | disclosed |
| US-20040180968-A1 | Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration | RASANEN TIINA-LIISA (FI) | 2004-09-16 | — | — | US | disclosed |
| JP-2004189714-A | MEDICINE FOR TREATING AND PREVENTING PANCREATITIS AND INDUCING HEPATIC REGENERATIVE FUNCTION | TIINA-LIISA RASANEN | 2004-07-08 | — | — | JP | disclosed |
| EP-1049444-B1 | REDUCTION OF HAIR GROWTH | GILLETTE CO (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-1049444-A1 | REDUCTION OF HAIR GROWTH | THE GILLETTE COMPANY (US) | 2000-11-08 | — | — | EP | disclosed |
| US-6060471-A | Reduction of hair growth | VLSI TECHNOLOGY, INC. | 2000-05-09 | — | — | US | disclosed |
| WO-1999037277-A1 | REDUCTION OF HAIR GROWTH | THE GILLETTE COMPANY (US) | 1999-07-29 | — | — | WO | disclosed |
| US-5344846-A | Administering aminoalkylguanidine; antitumor agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-09-06 | — | — | US | disclosed |
| WO-1994015596-A1 | COMPOSITIONS AND METHODS FOR INHIBITING DEOXYHYPUSINE SYNTHASE AND THE GROWTH OF CELLS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210030703-A1 | USE OF CALORIC RESTRICTION MIMETICS FOR POTENTIATING CHEMO-IMMUNOTHERAPY FOR THE TREATMENT OF CANCERS | CD274, PDCD1, PDCD10 | CA12 2812/4885CA2 2395/4885CA4 730/4885 |
| US-20040180968-A1 | Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration | SRM, SMOX, SMS | CA12 3648/4885CA2 4084/4885CA4 3959/4885 |
| US-10617656-B2 | Methods of increasing the cytotoxicity of chemotherapeutic agents with multisubstrate inhibitors of histone, protein-Lys, polyamine acetylation, and polyamine metabolism | KAT2A, HDAC1, HDAC10 | CA12 1923/4885CA2 991/4885CA4 1709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.