Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL28927062 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL29595491 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL30271 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL28649206 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL28518240 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL31157949 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL20455851 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL9143245 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL21145300 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL21145298 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 369 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12297347-B2 | Synthesis and characterization of well defined poly(propylene fumarate) and poly (ethylene glycol) block copolymers | THE UNIVERSITY OF AKRON (US) | 2025-05-13 | — | — | US | claimed |
| US-12187844-B2 | Block copolymers of lactones and poly(propylene fumarate) | THE UNIVERSITY OF AKRON (US) | 2025-01-07 | — | — | US | claimed |
| CN-118891297-A | Polymer bead composition and method for preparing polymer beads using the same | 株式会社阿斯帕 | 2024-11-01 | — | — | CN | claimed |
| US-20240324588-A1 | ESSENTIAL OIL MICROPARTICLES FOR POWDER COATING APPLICATIONS | Genesee Valley Innovations, LLC | 2024-10-03 | — | — | US | claimed |
| US-20240182747-A1 | SYNTHESIS AND 3D PRINTING OF TRIBLOCK COPOLYMER THROUGH ALTERNATING RING-OPENING COPOLYMERIZATION OF EPOXIDES WITH SATURATED AND UNSATURATED CYCLIC ANHYDRIDE | UNIV DUKE (US) | 2024-06-06 | — | — | US | claimed |
| US-11987668-B2 | Resorbable complex shape memory poly(propylene fumarate) star scaffolds for 4D printing applications | THE UNIVERSITY OF AKRON (US) | 2024-05-21 | — | — | US | claimed |
| EP-4301723-A1 | SYNTHESIS AND 3D PRINTING OF TRIBLOCK COPOLYMER | Becker, Matthew (US) | 2024-01-10 | — | — | EP | claimed |
| EP-4266124-A1 | TONER COMPOSITION | Xerox Corporation (US) | 2023-10-25 | — | — | EP | claimed |
| US-20230333495-A1 | Toner Composition | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT | 2023-10-19 | — | — | US | claimed |
| US-20230272159-A1 | RESORBABLE COMPLEX SHAPE MEMORY POLY(PROPYLENE FUMARATE) STAR SCAFFOLDS FOR 4D PRINTING APPLICATIONS | THE UNIVERSITY OF AKRON (US) | 2023-08-31 | — | — | US | claimed |
| EP-2666837-B1 | ADHESIVE RESIN COMPOSITION AND HOT-MELT ADHESIVE OBTAINED THEREFROM | MITSUI CHEMICALS INC (JP) | 2017-05-17 | — | — | EP | claimed |
| US-8530131-B2 | Toner compositions | XEROX CORPORATION (US) | 2013-09-10 | — | — | US | claimed |
| CN-1283215-C | Biodegradable carrier and delivery system for biologically active substances | SHUKLA A J (US) | 2006-11-08 | — | — | CN | claimed |
| EP-0994978-B1 | NONAQUEOUS SIZING SYSTEM FOR GLASS FIBERS AND INJECTION MOLDABLE POLYMERS | OWENS CORNING FIBERGLASS CORP (US) | 2004-10-06 | — | — | EP | claimed |
| CN-1438858-A | Biodegradable carrier and delivery system for biologically active substances | SHUKLA A J (US) | 2003-08-27 | — | — | CN | claimed |
| EP-0722971-B1 | Biodegradable compositions of synthetic and natural polymers | UNIV MINNESOTA (US) | 2001-01-03 | — | — | EP | claimed |
| EP-0355122-B1 | COMPOSITIONS OF POLYPHENYLENE OXIDES AND THERMOPLASTIC POLYMERS | ALLIED SIGNAL INC (US) | 1994-07-13 | — | — | EP | claimed |
| US-H1255-H | CONTAINING AN UNSATURATED POLYESTER AND A MONOMER FOR CURING POLYESTER | SHELL OIL COMPANY (US) | 1993-11-02 | — | — | US | claimed |
| EP-0260444-B1 | POLYOLEFIN FILM OR SHEET NOT CONTAINING A PLASTICIZER | ALKOR GMBH KUNSTSTOFFE (DE) | 1990-01-10 | — | — | EP | claimed |
| US-3956421-A | Polar thermoplastic additive for molding compounds and molding compound containing same | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1976-05-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240324588-A1 | ESSENTIAL OIL MICROPARTICLES FOR POWDER COATING APPLICATIONS | EXOSC9, EXOSC4, PHOSPHO1 | TSHR 3028/4885TP53 3636/4885EGLN1 3404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.