Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL28927062 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL29595491 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL28649206 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL28518240 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL31157949 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL20455851 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL344893 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL9143245 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL21145300 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL21145298 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3095 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122031763-A | Metabolizable multidirectional tensile hernia patch and preparation method thereof | 中国人民解放军总医院第四医学中心 | 2026-05-15 | — | — | CN | claimed |
| EP-3525722-B1 | DRUG ELUTING STENT FOR ENABLING RESTORATION OF FUNCTIONAL ENDOTHELIAL CELL LAYERS | SINO MEDICAL SCIENCES TECH INC (CN) | 2026-05-06 | — | — | EP | claimed |
| US-12618033-B2 | Multi-well plate and method for preparing same | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2026-05-05 | — | — | US | claimed |
| EP-3221379-B1 | WELL-DEFINED DEGRADABLE POLY(PROPYLENE FUMARATE) POLYMERS AND SCALABLE METHODS FOR THE SYNTHESIS THEREOF | UNIV AKRON (US) | 2026-04-29 | — | — | EP | claimed |
| US-12590188-B2 | Tri-block copolymers and nano-fibrous gelling microspheres including the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2026-03-31 | — | — | US | claimed |
| US-20260071025-A1 | SPIRO LACTIDE BASED COPOLYMERS | UNIV MICHIGAN REGENTS (US) | 2026-03-12 | — | — | US | claimed |
| US-20260061100-A1 | METHODS OF TREATING CARTILAGE WITH PSEUDOPLASTIC HYDROLYZED COLLAGEN-CONTAINING COMPOSITIONS | ROCHAL TECHNOLOGIES LLC (US) | 2026-03-05 | — | — | US | claimed |
| US-12564485-B2 | Tissue grafts with pre-made attachment points | AXOGEN CORPORATION (US) | 2026-03-03 | — | — | US | claimed |
| US-20260048175-A1 | THREE-DIMENSIONAL SCAFFOLD COMPOSITIONS AND METHODS FOR BONE REPAIR OR REGENERATION | UNIV RUTGERS (US) | 2026-02-19 | — | — | US | claimed |
| US-20260001980-A1 | MOLECULARLY ENGINEERED BRUSH-LIKE GRAFT COPOLYMERS AND COMPOSITIONS AND METHODS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2026-01-01 | — | — | US | claimed |
| EP-1003441-A1 | BIOERODIBLE POLYMERIC SEMI-INTERPENETRATING NETWORK ALLOYS FOR SURGICAL PLATES AND BONE CEMENTS, AND METHOD FOR MAKING SAME | CAMBRIDGE SCIENTIFIC, INC. (US) | 2000-05-31 | — | — | EP | claimed |
| WO-2000009043-A9 | OSTEOINDUCTION OF CORTICAL BONE ALLOGRAFTS BY COATING WITH BIOPOLYMERS SEEDED WITH RECIPIENT PERIOSTEAL BONE CELLS | CAMBRIDGE SCIENT INC (US) | 2000-05-18 | — | — | WO | claimed |
| WO-2000009043-A1 | OSTEOINDUCTION OF CORTICAL BONE ALLOGRAFTS BY COATING WITH BIOPOLYMERS SEEDED WITH RECIPIENT PERIOSTEAL BONE CELLS | CAMBRIDGE SCIENTIFIC, INC. (US) | 2000-02-24 | — | — | WO | claimed |
| WO-1999008627-A1 | RESORBABLE INTERBODY SPINAL FUSION DEVICES | CAMBRIDGE SCIENTIFIC, INC. (US) | 1999-02-25 | — | — | WO | claimed |
| WO-1998047445-A1 | BIOERODIBLE POLYMERIC SEMI-INTERPENETRATING NETWORK ALLOYS FOR SURGICAL PLATES AND BONE CEMENTS, AND METHOD FOR MAKING SAME | CAMBRIDGE SCIENTIFIC, INC. (US) | 1998-10-29 | — | — | WO | claimed |
| EP-0355122-B1 | COMPOSITIONS OF POLYPHENYLENE OXIDES AND THERMOPLASTIC POLYMERS | ALLIED SIGNAL INC (US) | 1994-07-13 | — | — | EP | claimed |
| US-H1255-H | CONTAINING AN UNSATURATED POLYESTER AND A MONOMER FOR CURING POLYESTER | SHELL OIL COMPANY (US) | 1993-11-02 | — | — | US | claimed |
| EP-0260444-B1 | POLYOLEFIN FILM OR SHEET NOT CONTAINING A PLASTICIZER | ALKOR GMBH KUNSTSTOFFE (DE) | 1990-01-10 | — | — | EP | claimed |
| US-4245006-A | POLYESTERURETHANE COATING | THE GENERAL TIRE & RUBBER COMPANY (US) | 1981-01-13 | — | — | US | claimed |
| US-3956421-A | Polar thermoplastic additive for molding compounds and molding compound containing same | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1976-05-11 | — | — | US | claimed |