Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449439 | 1.00 | PIM2 (0.47) | PIM2LRRK2BTKSTAT6NPC1 | |
| SCHEMBL3447978 | 0.92 | PIM2 (0.50) | PIM2BTKSTAT6NPC1RAB9A | |
| SCHEMBL3447975 | 0.92 | PIM2 (0.50) | PIM2BTKSTAT6NPC1RAB9A | |
| SCHEMBL13311469 | 0.90 | PIM2 (0.48) | PIM2BTKSTAT6NPC1RAB9A | |
| SCHEMBL13311434 | 0.90 | PIM2 (0.48) | PIM2BTKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3447480 | 0.90 | PIM2 (0.48) | PIM2BTKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3447477 | 0.90 | PIM2 (0.48) | PIM2BTKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13311549 | 0.90 | NPC1 (0.41) | PIM2LRRK2BTKSTAT6NPC1 | |
| SCHEMBL13311437 | 0.89 | PIM2 (0.51) | PIM2BTKSTAT6NPC1RAB9A | |
| SCHEMBL13311394 | 0.89 | PIM2 (0.47) | PIM2LRRK2BTKSTAT6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | PIM2 3060/4885LRRK2 4031/4885BTK 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.