Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | INPPL1 | O15357 | 5/20 | 0.37 |
| ▸ | INPP5A | Q14642 | 3/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | INPP5B | P32019 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL29070773 | 0.89 | TRPV1 (0.42) | APEX1TRPV1INPPL1INPP5AAKT1 | |
| SCHEMBL431782 | 0.89 | INPPL1 (0.46) | APEX1TRPV1INPPL1INPP5AAKT1 | |
| SCHEMBL30744579 | 0.89 | INPPL1 (0.46) | APEX1TRPV1INPPL1INPP5AAKT1 | |
| SCHEMBL29111142 | 0.87 | INPPL1 (0.42) | APEX1TRPV1INPPL1INPP5AAKT1 | |
| SCHEMBL28794879 | 0.87 | INPPL1 (0.44) | APEX1TRPV1INPPL1INPP5AAKT1 | |
| SCHEMBL30643908 | 0.87 | INPPL1 (0.44) | APEX1TRPV1INPPL1INPP5AAKT1 | |
| SCHEMBL6739019 | 0.87 | INPPL1 (0.44) | APEX1TRPV1INPPL1INPP5AAKT1 | |
| SCHEMBL27900451 | 0.87 | INPPL1 (0.44) | APEX1TRPV1INPPL1INPP5AAKT1 | |
| SCHEMBL21541942 | 0.87 | INPPL1 (0.44) | APEX1TRPV1INPPL1INPP5AAKT1 | |
| SCHEMBL27864987 | 0.87 | INPPL1 (0.44) | APEX1TRPV1INPPL1INPP5AAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 499 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118065177-A | Mirror surface release paper for leather and production process thereof | 江苏双淋新材料科技有限公司 | 2024-05-24 | — | — | CN | claimed |
| CN-111234395-B | Novel anti-agglomerating agents for the production of polyisobutene | 巴斯夫东南亚有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-117821009-A | Crystal drop glue and preparation method thereof | 南雄市沃太化工有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-117388413-A | Pretreatment method for synchronous detection of monomer and oligomeric organic phosphate in environmental medium | 江南大学 | 2024-01-12 | — | — | CN | claimed |
| WO-2023214485-A1 | RESIN COMPOSITION AND MOLDED ARTICLE | 三菱ケミカル株式会社 | 2023-11-09 | — | — | WO | claimed |
| CN-112646310-B | PC/ABS composite material and preparation method and application thereof | 武汉金发科技有限公司 | 2023-02-17 | — | — | CN | claimed |
| CN-114901739-A | Semiconductive layer composition for high voltage cable | 韩华思路信株式会社 | 2022-08-12 | — | — | CN | claimed |
| CN-114705784-A | Online detection method for organic phosphate in environmental water | 中国科学院生态环境研究中心 | 2022-07-05 | — | — | CN | claimed |
| CN-113943525-A | Water-soluble coating composition for finishing paint | ＫＣＣ公司 | 2022-01-18 | — | — | CN | claimed |
| CN-109423033-B | Thermoplastic resin composition having excellent thermal stability and low birefringence and molded article thereof | 现代摩比斯株式会社 | 2021-10-26 | — | — | CN | claimed |
| US-20080275160-A1 | Rubber compound for tire tread and method for the preparation thereof | MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) | 2008-11-06 | — | — | US | claimed |
| WO-2006136451-A1 | STABILISED POLYPROPYLENE COMPOSITION | BOREALIS TECHNOLOGY OY (FI) | 2006-12-28 | — | — | WO | claimed |
| EP-1736506-A1 | Stabilised polypropylene composition | Borealis Technology Oy (FI) | 2006-12-27 | — | — | EP | claimed |
| US-7026381-B2 | One-piece golf ball | SUMITOMO RUBBER INDUSTRIES, LTD. (JP) | 2006-04-11 | — | — | US | claimed |
| US-20060009568-A1 | Rubber compound for tire tread and method for the preparation thereof | MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) | 2006-01-12 | — | — | US | claimed |
| WO-2005097885-A2 | PRECIPITATION OF ADDITIVES IN OVER-SATURATED TRIBLOCK COPOLYMER ELASTOMERS | LAGHI ALDO A (US) | 2005-10-20 | — | — | WO | claimed |
| US-20050228088-A1 | Precipitation of additives in over-saturated triblock copolymer elastomers | ALPS SOUTH CORPORATION | 2005-10-13 | — | — | US | claimed |
| US-20040235588-A1 | One-piece golf ball | SRI SPORTS LIMITED (JP) | 2004-11-25 | — | — | US | claimed |
| US-20040175574-A1 | Golf ball | SRI SPORTS LIMITED (JP) | 2004-09-09 | — | — | US | claimed |
| WO-1992011319-A1 | METHODS AND COMPOSITIONS RELATING TO HALOGENATED POLYCARBONATE HAVING IMPROVED THERMAL STABILITY | THE DOW CHEMICAL COMPANY (US) | 1992-07-09 | — | — | WO | claimed |