Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 19/20 | 0.47 |
| ▸ | CDK2 | P24941 | 19/20 | 0.47 |
| ▸ | KDR | P35968 | 16/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450272 | 0.85 | GRM4 (0.44) | CDK1CDK2KDRGRM4 | |
| SCHEMBL3449221 | 0.84 | KDR (0.42) | CDK1CDK2KDR | |
| SCHEMBL3350947 | 0.81 | MAPK1 (0.51) | — | |
| SCHEMBL3448943 | 0.79 | PTK2 (0.50) | CDK1CDK2KDR | |
| SCHEMBL3448927 | 0.76 | CDK1 (0.44) | CDK1CDK2KDR | |
| SCHEMBL3450501 | 0.75 | HDAC3 (0.44) | CDK1CDK2KDR | |
| SCHEMBL3450174 | 0.74 | IDH1 (0.37) | CDK1CDK2KDRGRM4 | |
| SCHEMBL2514896 | 0.72 | GRM4 (0.48) | CDK2GRM4 | |
| SCHEMBL4584347 | 0.72 | IGF1R (0.48) | CDK1CDK2KDR | |
| SCHEMBL3344725 | 0.72 | CA12 (0.50) | CDK1CDK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | CDK1 1871/4885CDK2 2258/4885KDR 4837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.