Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20472729 | 0.86 | ALPL (0.44) | GSK3AGSK3BAAK1DGAT1PDGFRB | |
| SCHEMBL3606221 | 0.81 | GSK3A (0.44) | GSK3AGSK3BAAK1DGAT1PDGFRB | |
| SCHEMBL3412433 | 0.79 | GSK3A (0.41) | GSK3AGSK3BAAK1DGAT1PDGFRB | |
| SCHEMBL3798489 | 0.79 | PDGFRB (0.43) | GSK3AGSK3BKMT2AAAK1DGAT1 | |
| SCHEMBL3516528 | 0.79 | GSK3A (0.45) | GSK3AGSK3BKMT2AAAK1DGAT1 | |
| SCHEMBL6934738 | 0.78 | AAK1 (0.50) | GSK3AGSK3BAAK1DGAT1PDGFRB | |
| SCHEMBL462679 | 0.78 | AAK1 (0.47) | GSK3AGSK3BKMT2AAAK1DGAT1 | |
| SCHEMBL30864874 | 0.78 | AAK1 (0.45) | GSK3AGSK3BAAK1DGAT1PDGFRB | |
| SCHEMBL27314904 | 0.78 | AAK1 (0.45) | GSK3AGSK3BAAK1DGAT1PDGFRB | |
| SCHEMBL3516566 | 0.78 | GSK3A (0.40) | GSK3AGSK3BAAK1DGAT1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | GSK3A 3194/4885GSK3B 2904/4885KMT2A 4408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.