SCHEMBL345190

SCHEMBL345190

C=C(C)C(=O)NCc1cc(C(C)(C)CCCCC)cc(-n2nc3ccccc3n2)c1O

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 16/20 0.34
CNR1 P21554 16/20 0.34
GPR18 Q14330 3/20 0.34
GPR55 Q9Y2T6 3/20 0.34
TRPV1 Q8NER1 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
POLB P06746 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9408777 0.93 CNR2 (0.36) CNR2CNR1GPR18GPR55NPC1
SCHEMBL9408855 0.91 CNR2 (0.35) CNR2CNR1GPR18GPR55TRPV1
SCHEMBL9408878 0.90 CNR2 (0.35) CNR2CNR1GPR18GPR55NPC1
SCHEMBL9408826 0.89 NPC1 (0.41) CNR2CNR1GPR18GPR55NPC1
SCHEMBL508931 0.87 NPC1 (0.34) NPC1RAB9APOLB
SCHEMBL9408722 0.87 RAB9A (0.35) CNR2CNR1GPR18GPR55NPC1
SCHEMBL9249659 0.86 CNR2 (0.33) CNR2CNR1GPR18GPR55TRPV1
SCHEMBL345326 0.85 CNR2 (0.35) CNR2CNR1GPR18GPR55TRPV1
SCHEMBL9408807 0.85 CNR2 (0.35) CNR2CNR1GPR18GPR55NPC1
SCHEMBL1099131 0.84 POLB (0.34) CNR2CNR1GPR18GPR55NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4861840-A Novel siloxanyl acrylic monomer and gas-permeable contact lenses made therefrom BARNES-HIND, INC. (US) 1989-08-29 US claimed
EP-0293467-A1 NOVEL SILOXANYL ACRYLIC MONOMER AND GAS-PERMEABLE CONTACT LENSES MADE THEREFROM BARNES-HIND, INC. (US) 1988-12-07 EP claimed
US-4787904-A Hydrophillic intraocular lens SEVERIN SANFORD L (US) 1988-11-29 US claimed
WO-1988004299-A1 NOVEL SILOXANYL ACRYLIC MONOMER AND GAS-PERMEABLE CONTACT LENSES MADE THEREFROM BARNES-HIND, INC. (US) 1988-06-16 WO claimed
EP-3434226-B1 SYSTEMS FOR PLACEMENT OF CORNEAL IMPANTS SHIUEY YICHIEH (US) 2020-11-18 EP disclosed
EP-2954873-B1 CORNEAL IMPLANTS SHIUEY YICHIEH (US) 2019-11-06 EP disclosed
EP-3434226-A1 SYSTEMS FOR PLACEMENT OF CORNEAL IMPANTS Shiuey, Yichieh (US) 2019-01-30 EP disclosed
US-20180263756-A1 CORNEAL IMPLANTS AND METHODS AND SYSTEMS FOR PLACEMENT SHIUEY YICHIEH (US) 2018-09-20 US disclosed
US-9999497-B2 Corneal implants and methods and systems for placement SHIUEY YICHIEH (US) 2018-06-19 US disclosed
EP-2954873-A1 CORNEAL IMPLANTS Shiuey, Yichieh (US) 2015-12-16 EP disclosed
EP-2896386-A1 DEFORMABLE CORNEAL IMPLANTS Shiuey, Yichieh (US) 2015-07-22 EP disclosed
EP-1845897-B1 CORNEAL IMPLANTS AND SYSTEMS FOR PLACEMENT SHIUEY YICHIEH (US) 2015-03-04 EP disclosed
US-4861840-A Novel siloxanyl acrylic monomer and gas-permeable contact lenses made therefrom BARNES-HIND, INC. (US) 1989-08-29 US disclosed
EP-0203487-B1 COMPATIBLE POLYMER MIXTURES RÖHM GMBH (DE) 1989-03-22 EP disclosed
US-4814207-A SCRATCH AND WEATHER RESISTANT ROHM GMBH (DE) 1989-03-21 US disclosed
EP-0293467-A1 NOVEL SILOXANYL ACRYLIC MONOMER AND GAS-PERMEABLE CONTACT LENSES MADE THEREFROM BARNES-HIND, INC. (US) 1988-12-07 EP disclosed
US-4787904-A Hydrophillic intraocular lens SEVERIN SANFORD L (US) 1988-11-29 US disclosed
WO-1988004299-A1 NOVEL SILOXANYL ACRYLIC MONOMER AND GAS-PERMEABLE CONTACT LENSES MADE THEREFROM BARNES-HIND, INC. (US) 1988-06-16 WO disclosed
EP-0245728-A2 Process for producing scratch-proof and weather-resistant coatings on plastic objects RÖHM GMBH (DE) 1987-11-19 EP disclosed
EP-0203487-A1 Compatible polymer mixtures RÖHM GMBH (DE) 1986-12-03 EP disclosed