Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449663 | 0.89 | SYK (0.44) | CSNK2A1SYKEGFR | |
| SCHEMBL3449063 | 0.87 | MAPK1 (0.42) | SYKEGFRULK1 | |
| SCHEMBL3372082 | 0.87 | XDH (0.40) | XDHSLC22A12CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3449152 | 0.85 | XDH (0.43) | XDHSLC22A12CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3448975 | 0.84 | CSNK2A1 (0.39) | XDHSLC22A12CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3449066 | 0.84 | MAPK1 (0.47) | SYKULK1 | |
| SCHEMBL3447604 | 0.82 | CSNK2A1 (0.43) | XDHSLC22A12CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3450058 | 0.82 | XDH (0.42) | XDHSLC22A12CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3449010 | 0.82 | CSNK2A1 (0.45) | XDHSLC22A12CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3377106 | 0.81 | XDH (0.42) | XDHSLC22A12CSNK2A1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | XDH 39/4885SLC22A12 1529/4885CSNK2A1 1858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.