Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.58 |
| ▸ | ACHE | P22303 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529368 | 0.82 | BCHE (0.48) | BCHEACHEKMT2AGRIN2DGRIN3B | |
| SCHEMBL3453137 | 0.82 | HTR2A (0.49) | BCHEACHEKMT2AKDM4CGRIN2D | |
| SCHEMBL329846 | 0.81 | BCHE (0.49) | BCHEACHEKMT2AGRIN2DGRIN3B | |
| SCHEMBL1818790 | 0.80 | KMT2A (0.64) | BCHEKMT2AMAOATSHRKDM4C | |
| SCHEMBL13193462 | 0.80 | KMT2A (0.64) | BCHEKMT2AMAOATSHRKDM4C | |
| SCHEMBL1817701 | 0.79 | BCHE (0.65) | BCHEKMT2AMAOATSHRKDM4C | |
| SCHEMBL7851268 | 0.79 | KMT2A (0.71) | BCHEKMT2AMAOATSHRKDM4C | |
| SCHEMBL3667523 | 0.79 | BCHE (0.65) | BCHEKMT2AMAOATSHRKDM4C | |
| SCHEMBL11819007 | 0.79 | KMT2A (0.63) | BCHEKMT2AMAOATSHRKDM4C | |
| Bisobrin SCHEMBL11618791 | 0.79 | KMT2A (0.63) | BCHEKMT2AMAOATSHRKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820692-B2 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2010-10-26 | — | — | US | disclosed |
| US-20090275607-A1 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275607-A1 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | OPRK1, OPRD1, OPRL1 | BCHE 1556/4885ACHE 312/4885KMT2A 1319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.