Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28950037 | 0.94 | RAB9A (0.56) | RAB9ANPC1HPGDALDH1A1THRB | |
| SCHEMBL10907362 | 0.83 | IDO1 (0.51) | RAB9ANPC1HPGDALDH1A1THRB | |
| SCHEMBL17985011 | 0.81 | KDM4E (0.60) | RAB9ANPC1HPGDALDH1A1POLB | |
| SCHEMBL7981204 | 0.80 | CTNNB1 (0.60) | RAB9ANPC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3452459 | 0.80 | RAB9A (0.62) | RAB9ANPC1HPGDALDH1A1KDM4E | |
| SCHEMBL15942043 | 0.80 | RAB9A (0.54) | RAB9ANPC1HPGDALDH1A1POLB | |
| Iodide SCHEMBL6263376 | 0.80 | KDM4E (0.59) | RAB9ANPC1HPGDALDH1A1POLB | |
| SCHEMBL24760921 | 0.80 | ERCC5 (0.44) | RAB9ANPC1HPGDALDH1A1THRB | |
| SCHEMBL27332292 | 0.79 | NAPRT (0.54) | RAB9ANPC1HPGDALDH1A1POLB | |
| SCHEMBL11623530 | 0.78 | RAB9A (0.51) | RAB9ANPC1HPGDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896394-B1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | UNIV CALIFORNIA (US) | 2013-05-29 | — | — | EP | disclosed |
| US-7820663-B2 | Substituted enaminones, their derivatives and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-26 | — | — | US | disclosed |
| EP-1896394-A1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | The Regents of the University of California (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20060293329-A1 | Substituted enaminones, their derivatives and uses thereof | OXFORD FINANCE CORPORATION | 2006-12-28 | — | — | US | disclosed |
| WO-2006138510-A1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293329-A1 | Substituted enaminones, their derivatives and uses thereof | CHRNA7, CHRNA5, CHRNA1 | RAB9A 1092/4885NPC1 1996/4885HPGD 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.