Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3452959 | 1.00 | RAB9A (0.56) | RAB9AL3MBTL1KMT2ALMNAALDH1A1 | |
| SCHEMBL3559979 | 0.83 | CES2 (0.52) | RAB9AKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL4291907 | 0.80 | RAB9A (0.48) | RAB9AKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL4291901 | 0.80 | RAB9A (0.48) | RAB9AKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL7383383 | 0.78 | ALDH1A1 (0.58) | RAB9AKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL5318227 | 0.78 | ALDH1A1 (0.58) | RAB9AKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL13108901 | 0.78 | KMT2A (0.50) | RAB9AL3MBTL1KMT2ALMNAALDH1A1 | |
| SCHEMBL3452681 | 0.78 | KMT2A (0.50) | RAB9AL3MBTL1KMT2ALMNAALDH1A1 | |
| SCHEMBL3452683 | 0.78 | KMT2A (0.50) | RAB9AL3MBTL1KMT2ALMNAALDH1A1 | |
| SCHEMBL1081432 | 0.78 | ALDH1A1 (0.45) | RAB9AKMT2ALMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896394-B1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | UNIV CALIFORNIA (US) | 2013-05-29 | — | — | EP | disclosed |
| US-7820663-B2 | Substituted enaminones, their derivatives and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-26 | — | — | US | disclosed |
| EP-1896394-A1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | The Regents of the University of California (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20060293329-A1 | Substituted enaminones, their derivatives and uses thereof | OXFORD FINANCE CORPORATION | 2006-12-28 | — | — | US | disclosed |
| WO-2006138510-A1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293329-A1 | Substituted enaminones, their derivatives and uses thereof | CHRNA7, CHRNA5, CHRNA1 | RAB9A 1092/4885L3MBTL1 2808/4885KMT2A 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.