Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453342 | 1.00 | NPC1 (0.51) | NPC1RAB9AUSP2HTTPOLB | |
| SCHEMBL13108881 | 1.00 | NPC1 (0.51) | NPC1RAB9AUSP2HTTPOLB | |
| SCHEMBL2281472 | 0.84 | ALDH1A1 (0.55) | HTTPOLBSMN1; SMN2APPMAPT | |
| SCHEMBL4701109 | 0.80 | RAB9A (0.46) | NPC1RAB9APOLBTP53PAX8 | |
| SCHEMBL4701107 | 0.80 | RAB9A (0.46) | NPC1RAB9APOLBTP53PAX8 | |
| SCHEMBL12402287 | 0.79 | GAA (0.62) | NPC1RAB9AHTTPOLBSMN1; SMN2 | |
| SCHEMBL6779843 | 0.78 | PTGS2 (0.61) | NPC1RAB9APOLBSMN1; SMN2MAPT | |
| SCHEMBL6779837 | 0.78 | PTGS2 (0.61) | NPC1RAB9APOLBSMN1; SMN2MAPT | |
| SCHEMBL12626708 | 0.78 | PTGS2 (0.61) | NPC1RAB9APOLBSMN1; SMN2MAPT | |
| SCHEMBL28827968 | 0.77 | HPGD (0.62) | NPC1RAB9AHTTPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820705-B2 | Compounds and compositions as PPAR modulators | IRM LLC (BM) | 2010-10-26 | — | — | US | disclosed |
| EP-1745027-A4 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-06-03 | — | — | EP | disclosed |
| US-20080114044-A1 | Compounds And Compositions As Ppar Modulators | EPPLE ROBERT | 2008-05-15 | — | — | US | disclosed |
| EP-1745027-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM, LLC (BM) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005113519-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114044-A1 | Compounds And Compositions As Ppar Modulators | PPARG, PPARA, PPARD | NPC1 425/4885RAB9A 2891/4885USP2 4015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.