Indole

Indole

SCHEMBL345395

CC=O.c1ccc2[nH]ccc2c1

nearest known ligand 0.74

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 7/20 0.74
CA1 P00915 2/20 0.74
CA4 P22748 2/20 0.74
CA6 P23280 2/20 0.74
TRPA1 O75762 1/20 0.74
CA2 P00918 1/20 0.74
ITGB2 P05107 1/20 0.74
ICAM1 P05362 1/20 0.74
ITGAL P20701 1/20 0.74
ADK P55263 1/20 0.74
CYP2A6 P11509 4/20 0.47
NPC1 O15118 2/20 0.42
PARP1 P09874 1/20 0.42
ALDH1A1 P00352 2/20 0.39
CA12 O43570 1/20 0.39
CA3 P07451 1/20 0.39
CA5A P35218 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA13 Q8N1Q1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indole SCHEMBL11402854 0.89 AHR (0.77) AHRCA1CA4CA6TRPA1
Indole SCHEMBL27500374 0.88 AHR (0.68) AHRCA1CA4CA6TRPA1
Indole SCHEMBL30042337 0.87 AHR (0.74) AHRCA1CA4CA6TRPA1
Indole SCHEMBL21723436 0.87 AHR (0.74) AHRCA1CA4CA6TRPA1
Indole SCHEMBL20819817 0.87 AHR (0.74) AHRCA1CA4CA6TRPA1
Indole SCHEMBL27679207 0.87 AHR (0.74) AHRCA1CA4CA6TRPA1
Indole SCHEMBL28241238 0.87 AHR (0.74) AHRCA1CA4CA6TRPA1
Indole SCHEMBL27957692 0.86 AHR (0.90) AHRCA1CA4CA6TRPA1
Indole SCHEMBL30463845 0.86
Indole SCHEMBL30250492 0.86

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250324977-A1 ENGINEERED BACTERIA FOR ENHANCED CROP PRODUCTION UNIV CALIFORNIA (US) 2025-10-23 US claimed
WO-2023235512-A2 ENGINEERED BACTERIA FOR ENHANCED CROP PRODUCTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-12-07 WO claimed
CN-114487416-A Intracranial aneurysm-related plasma metabolism markers and application thereof 南方医科大学珠江医院 2022-05-13 CN claimed
CN-109234245-B Indole acetaldehyde dehydrogenase gene ald2 and overexpression and application thereof 南京农业大学 2022-04-22 CN claimed
CN-1207569-C Method for assaying virus-containing sample, virus assaying method and diagnostic kit ADVANCED LIFE SCIENCE INST INC (JP) 2005-06-22 CN claimed
CN-1239548-A Method for detecting or determining viruses TONEN CORP (JP) 1999-12-22 CN claimed
US-20250324977-A1 ENGINEERED BACTERIA FOR ENHANCED CROP PRODUCTION UNIV CALIFORNIA (US) 2025-10-23 US disclosed
EP-4587116-A2 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES MarvelBiome, Inc. (US) 2025-07-23 EP disclosed
WO-2024229110-A1 INDOLE LACTATE FOR THE TREATMENT OF MULTIPLE SCLEROSIS THE JOHNS HOPKINS UNIVERSITY (US) 2024-11-07 WO disclosed
US-20240110192-A1 BACTERIA ENGINEERED TO TREAT DISEASES THAT BENEFIT FROM REDUCED GUT INFLAMMATION AND/OR TIGHTENED GUT MUCOSAL BARRIER SYNLOGIC OPERATING COMPANY, INC. (US) 2024-04-04 US disclosed
WO-2024058984-A2 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES MarvelBiome, Inc. (US) 2024-03-21 WO disclosed
EP-3164495-B1 MICROORGANISMS FOR PRODUCING 4C-5C COMPOUNDS WITH UNSATURATION AND METHODS RELATED THERETO GENOMATICA INC (US) 2024-02-28 EP disclosed
US-11896627-B2 Bacteria engineered to treat metabolic diseases SYNLOGIC OPERATING COMPANY, INC. (US) 2024-02-13 US disclosed
US-20010044381-A1 Aspartic acid derivative-containing compositions and use thereof in stimulating and/or regulating plant and plant precursor growth LIDOCHEM INC. 2001-11-22 US disclosed
US-6245717-B1 APPLYING 4-PHENYLBUTYRIC ACID TO IMPROVE CROP YIELD COMPASS BANK 2001-06-12 US disclosed
US-6239073-B1 CYCLOPENTYL-SUBSTITUTED BRASSINOSTEROIDS HAVING HIGH GROWTH PROMOTING ABILITY EXELIXIS PLANT SCIENCES, INC. 2001-05-29 US disclosed
WO-2000058338-A1 BRASSINOSTEROID ANALOGS USEFUL AS PLANT GROWTH REGULATORS AGRITOPE, INC. (US) 2000-10-05 WO disclosed
US-6063731-A COMPOUNDS WHICH PROMOTE PLANT GROWTH AGRITOPE, INC. (US) 2000-05-16 US disclosed
CN-1239548-A Method for detecting or determining viruses TONEN CORP (JP) 1999-12-22 CN disclosed
EP-0506532-A1 Indole derivatives, process for their preparation and medicaments containing them LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1992-09-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240110192-A1 BACTERIA ENGINEERED TO TREAT DISEASES THAT BENEFIT FROM REDUCED GUT INFLAMMATION AND/OR TIGHTENED GUT MUCOSAL BARRIER FABP2, TLR9, LY96 AHR 416/4885CA1 3282/4885CA4 1675/4885
US-11896627-B2 Bacteria engineered to treat metabolic diseases GOT2, BPGM, MLYCD AHR 985/4885CA1 4844/4885CA4 3435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.