Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.52 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28096188 | 0.80 | BCAT2 (0.67) | PLA2G2ABCAT2BAZ2BBAZ2APRKCI | |
| SCHEMBL27361722 | 0.77 | BCAT2 (0.58) | PLA2G2ABCAT2BAZ2BBAZ2ADHODH | |
| SCHEMBL5608859 | 0.77 | FAAH (0.42) | PLA2G2AFAAHPLA2G10SIRT2 | |
| SCHEMBL10189495 | 0.76 | PARP1 (0.56) | PLA2G2APLA2G10FOLH1 | |
| SCHEMBL5307077 | 0.76 | PARP1 (0.56) | PLA2G2ABCAT2BAZ2BBAZ2APRKCI | |
| SCHEMBL5476512 | 0.75 | BCAT2 (0.59) | BCAT2SIRT2FOLH1NPC1RAB9A | |
| SCHEMBL11901439 | 0.73 | SIRT2 (0.64) | PLA2G2ABCAT2PLA2G10SIRT2HDAC8 | |
| SCHEMBL27787423 | 0.72 | BCAT2 (0.65) | BCAT2SIRT2FOLH1NPC1RAB9A | |
| SCHEMBL1667780 | 0.72 | PTGER1 (0.72) | PTGER1 | |
| SCHEMBL4439618 | 0.71 | BCAT2 (0.62) | BCAT2SIRT2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | claimed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |