Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482646 | 0.88 | PPARG (0.45) | BCAT2PPARGLTB4R2SMN1; SMN2NPC1 | |
| SCHEMBL28149292 | 0.88 | BCAT2 (0.50) | BCAT2PPARGLTB4R2MEN1KMT2A | |
| SCHEMBL4439618 | 0.87 | BCAT2 (0.62) | BCAT2HNF4ALTB4R2MEN1KMT2A | |
| SCHEMBL17558558 | 0.84 | BCAT2 (0.42) | BCAT2HNF4ALTB4R2MEN1KMT2A | |
| SCHEMBL370726 | 0.83 | MYC (0.45) | BCAT2PPARGMEN1KMT2AKEAP1 | |
| SCHEMBL2964481 | 0.83 | PARP1 (0.45) | BCAT2MEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL27787423 | 0.82 | BCAT2 (0.65) | BCAT2HNF4AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5478290 | 0.82 | PARP1 (0.45) | BCAT2PPARGMEN1KMT2AKEAP1 | |
| SCHEMBL16463457 | 0.81 | PARP1 (0.40) | BCAT2PPARGMEN1KMT2ASYK | |
| SCHEMBL5478916 | 0.81 | MEN1 (0.44) | BCAT2PPARGMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148974-B1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | ST EUROPEO DI ONCOLOGIA S R L (IT) | 2018-09-26 | — | — | EP | disclosed |
| EP-3148974-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | Istituto Europeo di Oncologia S.r.l. (IT) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181380-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2015-12-03 | — | — | WO | disclosed |
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| EP-1644397-A1 | SPECIFIC GLUCOCORTICOSTEROID COMPOUND HAVING ANTI- INFLAMMATORY ACTIVITY | GLAXO GROUP LIMITED (GB) | 2006-04-12 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |
| WO-2005005452-A1 | SPECIFIC GLUCOCORTICOSTEROID COMPOUND HAVING ANTI- INFLAMMATORY ACTIVITY | GLAXO GROUP LIMITED (GB) | 2005-01-20 | — | — | WO | disclosed |
| CN-1098255-C | Novel substituted piperazine derivatives having tachyknin receptor antagonists activity | AVENTIS PHARMA INC (US) | 2003-01-08 | — | — | CN | disclosed |
| CN-1083429-C | Substituted alkyldiamine derivatives and their use as tachykinin antagonists | MERRELL PHARMA INC (US) | 2002-04-24 | — | — | CN | disclosed |
| CN-1181753-A | Novel substituted piperazine derivatives having tachyknin receptor antagonists activity | HOECHST MARION ROUSSEL INC (US) | 1998-05-13 | — | — | CN | disclosed |
| CN-1155883-A | Substituted alkyldiamine derivatives and their use as tachykinin antagonists | MERRELL PHARMA INC (US) | 1997-07-30 | — | — | CN | disclosed |