SCHEMBL3454141

SCHEMBL3454141

COC(=O)Oc1nc(-c2ccc(F)c(F)c2F)cc(NC(C)=O)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.39
ALDH1A1 P00352 3/20 0.37
ADORA3 P0DMS8 4/20 0.36
ADORA2A P29274 2/20 0.36
ABL1 P00519 2/20 0.36
KDM4E B2RXH2 2/20 0.36
HSD17B10 Q99714 2/20 0.36
RIPK1 Q13546 3/20 0.36
TRPV3 Q8NET8 1/20 0.35
TGFBR1 P36897 1/20 0.35
PIK3CA P42336 1/20 0.35
MTOR P42345 1/20 0.35
SCN9A Q15858 1/20 0.34
SCN2A Q99250 1/20 0.34
SCN3A Q9NY46 1/20 0.34
SCN10A Q9Y5Y9 1/20 0.34
IDH1 O75874 1/20 0.34
NPC1 O15118 1/20 0.34
HPGD P15428 1/20 0.34
NFKB1 P19838 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2467053 0.91 PIK3CA (0.36) POLBALDH1A1ADORA3ADORA2AABL1
SCHEMBL2468173 0.91 ADORA2A (0.39) POLBALDH1A1ADORA3ADORA2AABL1
SCHEMBL17797217 0.91 KDM4E (0.39) POLBALDH1A1ADORA3ADORA2AABL1
SCHEMBL2464613 0.88 ADORA2A (0.39) ALDH1A1ADORA3ADORA2AABL1KDM4E
SCHEMBL2468304 0.87 ALDH1A1 (0.38) POLBALDH1A1ADORA3ADORA2AABL1
SCHEMBL2465978 0.87 ALDH1A1 (0.38) ALDH1A1ADORA3ADORA2AABL1RIPK1
SCHEMBL3329878 0.85 ALDH1A1 (0.40) POLBALDH1A1ADORA3ADORA2AABL1
SCHEMBL2470061 0.85 PDCD1LG2 (0.35) ABL1TRPV3SCN9ASCN2ASCN3A
SCHEMBL2468120 0.84 ALDH1A1 (0.36) ALDH1A1ADORA3ADORA2AABL1RIPK1
SCHEMBL17797223 0.84 RORC (0.40) ALDH1A1ADORA3ABL1KDM4ERIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed