SCHEMBL3454232

SCHEMBL3454232

CC(C)c1ccc(N=C=O)c(I)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.39
ALDH1A1 P00352 3/20 0.39
HPGD P15428 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
TRPA1 O75762 2/20 0.37
RNASEH1 O60930 1/20 0.33
LMNA P02545 1/20 0.33
TYR P14679 3/20 0.33
PTGS1 P23219 1/20 0.32
CACNA1C Q13936 1/20 0.32
ALOX12 P18054 2/20 0.32
HTT P42858 2/20 0.32
GAA P10253 1/20 0.32
HIF1A Q16665 1/20 0.32
KDM4E B2RXH2 1/20 0.30
MDM4 O15151 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
TP53 P04637 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11114239 0.83 CYP3A4 (0.42) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL9623236 0.80 CYP3A4 (0.40) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL9835715 0.79 TDP1 (0.39) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL7591507 0.76 CYP3A4 (0.38) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL22815459 0.76 CYP3A4 (0.59) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL5481480 0.76 CYP3A4 (0.45) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL20798330 0.72 CYP3A4 (0.38) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL10945564 0.70 CYP3A4 (0.37) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL112207 0.70 CYP3A4 (0.46) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL19122653 0.69 LMNA (0.44) CYP3A4ALDH1A1HPGDTDP1TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2254889-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF Merck Patent GmbH (DE) 2010-12-01 EP disclosed
WO-2009108670-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK SERONO S.A. (CH) 2009-09-03 WO disclosed