SCHEMBL7591507

SCHEMBL7591507

CC(C)c1ccc(C(C)C)c(N=C=O)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.38
TRPA1 O75762 2/20 0.38
TDP1 Q9NUW8 3/20 0.36
ALDH1A1 P00352 3/20 0.36
HPGD P15428 2/20 0.36
LMNA P02545 1/20 0.34
RNASEH1 O60930 1/20 0.34
TYR P14679 3/20 0.33
MAPT P10636 2/20 0.33
MAPK1 P28482 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
PTGS1 P23219 1/20 0.33
CACNA1C Q13936 1/20 0.33
EIF4A3 P38919 1/20 0.33
FABP3 P05413 2/20 0.32
FABP4 P15090 2/20 0.32
ALOX12 P18054 2/20 0.32
HTT P42858 2/20 0.32
GAA P10253 1/20 0.32
HIF1A Q16665 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9623236 0.85 CYP3A4 (0.40) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL11114239 0.85 CYP3A4 (0.42) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL22815459 0.81 CYP3A4 (0.59) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL29376285 0.81 CYP3A4 (0.59) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL133880 0.81 CYP3A4 (0.59) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL28573888 0.80 CYP3A4 (0.41) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL17118293 0.79 LMNA (0.40) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL627035 0.78 CYP3A4 (0.34) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL3454232 0.76 CYP3A4 (0.39) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL9835715 0.76 TDP1 (0.39) CYP3A4TRPA1TDP1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020123594-A1 Polyurethane prepolymers and polyurethane elastomers based on 1,4-naphthalene diisocyanate BAYER AKTIENGESELLSCHAFT (DE) 2002-09-05 US disclosed
WO-2002046259-A1 POLYURETHANE PREPOLYMER AND POLYURETHANE ELASTOMERS, BASED ON 1,4-NAPHTHALENE DI-ISOCYANATE BAYER AKTIENGESELLSCHAFT (DE) 2002-06-13 WO disclosed
US-5589601-A POLYMERIZATION WITH COORDINATION CATALYST OF TUNGSTEN OXYHALIDE, ARYL ISOCYANATE OR DIISOCYANATE AND ALKYLALUMINUM HALIDE INSTITUT FRANCAIS DU PETROLE (FR) 1996-12-31 US disclosed