Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3040107 | 0.73 | HDAC1 (0.50) | HDAC1HDAC6HDAC8HDAC3HDAC11 | |
| SCHEMBL3650222 | 0.73 | RAB9A (0.43) | HDAC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8575405 | 0.72 | OGG1 (0.67) | HDAC1HDAC6HDAC8HDAC3HDAC7 | |
| SCHEMBL3721966 | 0.71 | NCEH1 (0.38) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL691761 | 0.70 | KMT2A (0.56) | HDAC1HDAC3HDAC2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27743016 | 0.70 | OGG1 (0.64) | HDAC1HDAC6HDAC8HDAC3HDAC7 | |
| SCHEMBL3037611 | 0.69 | ALDH1A1 (0.62) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3033752 | 0.69 | HDAC6 (0.73) | HDAC1HDAC6HDAC8HDAC3HDAC11 | |
| SCHEMBL1845922 | 0.69 | MEN1 (0.40) | HDAC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3028724 | 0.69 | HDAC6 (0.76) | HDAC1HDAC6HDAC8HDAC3HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | disclosed |