Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3456238 | 0.80 | GPR119 (0.35) | GPR119 | |
| SCHEMBL3067369 | 0.78 | MAPT (0.34) | KDM4EALDH1A1 | |
| SCHEMBL3073015 | 0.74 | GPR119 (0.33) | GPR119KDM4E | |
| SCHEMBL4242556 | 0.74 | MEN1 (0.35) | GPR119KDM4E | |
| SCHEMBL3454830 | 0.69 | GPR119 (0.46) | GPR119USP30TGFBR1PIK3CAMTOR | |
| SCHEMBL14157779 | 0.65 | GPR119 (0.54) | GPR119KDM4EALDH1A1 | |
| SCHEMBL15507106 | 0.65 | GPR119 (1.00) | GPR119 | |
| SCHEMBL30366165 | 0.64 | GPR119 (0.56) | GPR119ALDH1A1 | |
| SCHEMBL23410150 | 0.63 | GPR119 (0.61) | GPR119USP30TGFBR1 | |
| SCHEMBL22324934 | 0.63 | GPR119 (0.55) | GPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166850-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | High Point Pharmaceuticals, LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154126-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-12-18 | — | — | WO | disclosed |