Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3456235 | 0.80 | GPR119 (0.36) | GPR119 | |
| SCHEMBL3067368 | 0.76 | ALDH1A1 (0.35) | TGFBR1 | |
| SCHEMBL4242555 | 0.74 | PLAT (0.35) | GPR119 | |
| SCHEMBL3073012 | 0.74 | PLAT (0.35) | GPR119 | |
| SCHEMBL3454833 | 0.69 | GPR119 (0.48) | GPR119IDH1USP30TGFBR1PIK3CA | |
| SCHEMBL30366165 | 0.69 | GPR119 (0.56) | GPR119LMNADDB1CRBN | |
| SCHEMBL22324934 | 0.68 | GPR119 (0.55) | GPR119LMNA | |
| SCHEMBL3455672 | 0.67 | LRRK2 (0.39) | PIK3CATBK1DDB1CRBN | |
| SCHEMBL23410150 | 0.66 | GPR119 (0.61) | GPR119USP30LMNATGFBR1 | |
| SCHEMBL10162809 | 0.66 | GPR119 (0.58) | GPR119USP30LMNATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166850-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | High Point Pharmaceuticals, LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154126-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-12-18 | — | — | WO | disclosed |