Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3456017 | 0.86 | ALPL (0.42) | GAAKDM4ELMNAKMT2AMEN1 | |
| SCHEMBL14031961 | 0.84 | KDM4E (0.38) | GAAKDM4EMAPTLMNAKMT2A | |
| SCHEMBL3455923 | 0.84 | KMT2A (0.40) | KDM4EMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3455927 | 0.79 | PKM (0.43) | GAAKDM4EMAPTSMN1; SMN2LMNA | |
| SCHEMBL3456385 | 0.78 | GRIN2D (0.39) | GAAKDM4EMAPTSMN1; SMN2KMT2A | |
| SCHEMBL3455883 | 0.78 | GUSB (0.42) | MAPTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL3455987 | 0.73 | MAPT (0.46) | GAAKDM4EMAPTSMN1; SMN2LMNA | |
| SCHEMBL3458954 | 0.70 | CD4 (0.43) | KDM4EMAPTSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL3455109 | 0.69 | NPC1 (0.40) | KDM4EMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3458009 | 0.69 | NPC1 (0.39) | GAAKDM4EMAPTSMN1; SMN2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |