Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455894 | 0.86 | GAA (0.49) | GAAMEN1KMT2APKMNMT1 | |
| SCHEMBL3455923 | 0.85 | KMT2A (0.40) | MEN1KMT2AKDM4ETP53NPC1 | |
| SCHEMBL14031961 | 0.82 | KDM4E (0.38) | GAAMEN1KMT2AKDM4ELMNA | |
| SCHEMBL3463347 | 0.80 | MCOLN3 (0.44) | GAAKMT2APKMLMNATP53 | |
| SCHEMBL3456385 | 0.76 | GRIN2D (0.39) | GAAKMT2AKDM4ETP53NPC1 | |
| SCHEMBL3455883 | 0.74 | GUSB (0.42) | MEN1KMT2ALMNAALOX12NPC1 | |
| SCHEMBL3458954 | 0.69 | CD4 (0.43) | KDM4ENPC1RAB9A | |
| SCHEMBL14032053 | 0.68 | MAPT (0.58) | GAAMEN1KMT2APKMKDM4E | |
| SCHEMBL3455109 | 0.68 | NPC1 (0.40) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL3455927 | 0.68 | PKM (0.43) | GAAMEN1KMT2APKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |