Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 16/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457104 | 0.93 | P2RX7 (0.51) | P2RX7 | |
| SCHEMBL14031932 | 0.90 | P2RX7 (0.41) | P2RX7LMNAHPGDPDE10A | |
| SCHEMBL3457136 | 0.87 | MTHFD2 (0.41) | — | |
| SCHEMBL14031928 | 0.85 | HPSE (0.39) | P2RX7LMNAHTT | |
| SCHEMBL14032078 | 0.85 | KMT2A (0.40) | P2RX7ALDH1A1LMNAHPGDHTT | |
| SCHEMBL14031826 | 0.85 | TSHR (0.41) | P2RX7ALDH1A1LMNAHPGDHTT | |
| SCHEMBL3455647 | 0.85 | SMN1; SMN2 (0.43) | LMNAPDE4B | |
| SCHEMBL14032050 | 0.85 | POLB (0.44) | LMNAHTT | |
| SCHEMBL3455611 | 0.85 | GRM5 (0.43) | P2RX7ALDH1A1HTTPDE4B | |
| SCHEMBL14032039 | 0.85 | PRSS12 (0.41) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |