Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457560 | 0.94 | DRD2 (0.41) | GRIN2BGRM2KMT2AHTR1ADRD2 | |
| SCHEMBL3455866 | 0.89 | DRD2 (0.44) | PARP1MEN1KMT2ADRD2DRD3 | |
| SCHEMBL3460034 | 0.86 | ALDH1A1 (0.37) | GRIN2BMEN1KMT2AHTR1A | |
| SCHEMBL3455936 | 0.84 | ALDH1A1 (0.38) | MEN1KMT2A | |
| SCHEMBL3455100 | 0.82 | BRD4 (0.38) | MEN1KMT2A | |
| SCHEMBL3461019 | 0.82 | GRIA1 (0.39) | MEN1KMT2A | |
| SCHEMBL14032049 | 0.81 | GPBAR1 (0.42) | KMT2A | |
| SCHEMBL3456801 | 0.81 | KIT (0.41) | GRM2DRD2 | |
| SCHEMBL3455104 | 0.81 | MEN1 (0.47) | SIGMAR1MEN1KMT2ADRD2DRD3 | |
| SCHEMBL3462996 | 0.80 | ALDH1A1 (0.36) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |