Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3456014 | 0.94 | GRIN2B (0.41) | DRD2HTR1ADRD3GRM2KMT2A | |
| SCHEMBL3455866 | 0.90 | DRD2 (0.44) | DRD2DRD4DRD3BRS3CYP1A2 | |
| SCHEMBL3455936 | 0.86 | ALDH1A1 (0.38) | CYP1A2CYP2C9CYP2C19SMN1; SMN2METAP2 | |
| SCHEMBL3460034 | 0.84 | ALDH1A1 (0.37) | HTR1ASMN1; SMN2METAP2METAP1CBFB | |
| SCHEMBL3455100 | 0.84 | BRD4 (0.38) | CYP1A2CYP2C9CYP2C19SMN1; SMN2METAP2 | |
| SCHEMBL3461019 | 0.83 | GRIA1 (0.39) | CYP1A2CYP2C9CYP2C19SMN1; SMN2CYP3A4 | |
| SCHEMBL14032049 | 0.83 | GPBAR1 (0.42) | CYP1A2CYP2C9CYP2C19SMN1; SMN2CYP3A4 | |
| SCHEMBL5067955 | 0.82 | SMN1; SMN2 (0.45) | CYP1A2CYP2C9CYP2C19SMN1; SMN2CYP3A4 | |
| SCHEMBL3456801 | 0.82 | KIT (0.41) | DRD2CYP3A4GRM2CLPP | |
| SCHEMBL3455104 | 0.82 | MEN1 (0.47) | DRD2DRD4DRD3MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |