Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3458954 | 0.85 | CD4 (0.43) | ALDH1A1NPC1RAB9AATMERAP1 | |
| SCHEMBL14031947 | 0.85 | NPC1 (0.40) | AMY1AALDH1A1POLBGAAKMT2A | |
| SCHEMBL3455927 | 0.83 | PKM (0.43) | AMY1AALDH1A1GAAUSP2KMT2A | |
| SCHEMBL3457131 | 0.83 | GRM5 (0.38) | ALDH1A1POLBGAAUSP2KMT2A | |
| SCHEMBL3459484 | 0.82 | NPC1 (0.39) | AMY1APOLBKMT2ANPC1RAB9A | |
| SCHEMBL3455987 | 0.82 | MAPT (0.46) | AMY1AALDH1A1POLBGAAUSP2 | |
| SCHEMBL3458009 | 0.82 | NPC1 (0.39) | ALDH1A1GAAUSP2KMT2ANPC1 | |
| SCHEMBL3455272 | 0.81 | HTR6 (0.43) | AMY1AALDH1A1POLBKMT2ANPC1 | |
| SCHEMBL3455109 | 0.81 | NPC1 (0.40) | AMY1AALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL3456017 | 0.80 | ALPL (0.42) | GAAKMT2ANPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |