Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 15/20 | 0.54 |
| ▸ | CTSS | P25774 | 15/20 | 0.54 |
| ▸ | CTSK | P43235 | 15/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | BTD | P43251 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347517 | 0.92 | CTSB (0.64) | CTSBCTSSCTSK | |
| SCHEMBL347111 | 0.88 | CTSB (0.56) | CTSBCTSSCTSKCYP3A4 | |
| SCHEMBL345708 | 0.87 | CTSB (0.61) | CTSBCTSSCTSK | |
| SCHEMBL8223759 | 0.86 | CTSB (0.54) | CTSBCTSSCTSKCYP3A4VNN1 | |
| SCHEMBL347367 | 0.85 | CTSB (0.75) | CTSBCTSSCTSK | |
| SCHEMBL345973 | 0.85 | CTSB (0.53) | CTSBCTSSCTSK | |
| SCHEMBL12236966 | 0.84 | CTSB (0.57) | CTSBCTSSCTSK | |
| SCHEMBL347222 | 0.82 | CTSB (0.58) | CTSBCTSSCTSK | |
| SCHEMBL347518 | 0.79 | CTSS (0.70) | CTSBCTSSCTSK | |
| SCHEMBL347248 | 0.78 | CTSS (0.69) | CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073662-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI (FR) | 2014-03-13 | — | — | US | disclosed |
| US-8609681-B2 | Spirocyclic nitriles as protease inhibitors | SANOFI (FR) | 2013-12-17 | — | — | US | disclosed |
| US-20120015933-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2012-01-19 | — | — | US | disclosed |
| US-8039480-B2 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2011-10-18 | — | — | US | disclosed |
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | CTSB 31/4885CTSS 24/4885CTSK 87/4885 |
| US-20120015933-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | CTSB 31/4885CTSS 24/4885CTSK 87/4885 |
| US-20140073662-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | CTSB 31/4885CTSS 24/4885CTSK 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.