Gacyclidine

Gacyclidine

SCHEMBL3457748

CC1CCCCC1(c1cccs1)N1CCCCC1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.57
PRCP P42785 2/20 0.57
MEN1 O00255 1/20 0.57
KMT2A Q03164 1/20 0.57
SLC6A3 Q01959 1/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.40
CHRM3 P20309 2/20 0.39
OPRM1 P35372 1/20 0.39
OPRL1 P41146 1/20 0.39
SLC6A9 P48067 2/20 0.38
CHRM2 P08172 1/20 0.38
CHRM4 P08173 1/20 0.38
CHRM5 P08912 1/20 0.38
CHRM1 P11229 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gacyclidine SCHEMBL7190367 1.00 SIGMAR1 (0.57) SIGMAR1PRCPMEN1KMT2ASLC6A3
Gacyclidine SCHEMBL4465879 1.00 SIGMAR1 (0.57) SIGMAR1PRCPMEN1KMT2ASLC6A3
Gacyclidine SCHEMBL397836 1.00 SIGMAR1 (0.57) SIGMAR1PRCPMEN1KMT2ASLC6A3
Gacyclidine SCHEMBL5398234 0.99 SIGMAR1 (0.56) SIGMAR1PRCPMEN1KMT2ASLC6A3
Gacyclidine SCHEMBL1662223 0.99 SIGMAR1 (0.56) SIGMAR1PRCPMEN1KMT2ASLC6A3
SCHEMBL8206550 0.83 MEN1 (0.42) SIGMAR1PRCPMEN1KMT2ASLC6A3
Hydrochloric Acid SCHEMBL8205944 0.82 MEN1 (0.41) SIGMAR1PRCPMEN1KMT2ASLC6A3
SCHEMBL7700857 0.81 PRCP (0.51) SIGMAR1PRCPMEN1KMT2ASLC6A3
Gacyclidine SCHEMBL5402379 0.79 CYP1A2 (0.45) SIGMAR1PRCPMEN1KMT2ASLC6A3
Gacyclidine SCHEMBL14053284 0.78 GRIN1 (0.56) SIGMAR1PRCPMEN1KMT2ASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114828848-A Intranasal dantrolene administration for the treatment of alzheimer's disease 宾夕法尼亚大学理事会 2022-07-29 CN claimed
WO-2022140636-A1 GACYCLIDINE OTIC FORMULATIONS AND USES THEREOF OTONOMY, INC. (US) 2022-06-30 WO claimed
WO-2010142890-A1 COMPOSITION INCLUDING A MOLECULE PROMOTING THE NEURON-GLIA INTERACTION, IN PARTICULAR FOR PREVENTING THE FORMATION OF THE GLIAL SCAR AND INDUCING NEURAL REGENERATION NEUREVA (FR) 2010-12-16 WO claimed
US-20090023780-A1 Therapeutic use of a derivative of thienylcyclohexylamine SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) 2009-01-22 US claimed
EP-1359914-B1 NOVEL THERAPEUTIC USE OF A THIENYLCYCLOHEXYLAMINE DERIVATIVE FOR TREATING PAIN SOD CONSEILS RECH APPLIC (FR) 2006-08-30 EP claimed
US-20050032840-A1 Novel therapeutic use of a thienylcyclohexylamine derivative NEUREVA (FR) 2005-02-10 US claimed
US-6784194-B2 FOR INHIBITING EFFECTS OF EXOGENOUS NEUROTOXIC OR NEUROTOXINIC PRODUCTS IN WARM-BLOODED ANIMALS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2004-08-31 US claimed
EP-0956019-B1 NOVEL THERAPEUTIC APPLICATION OF A THIENYCYCLOHEXYLAMINE DERIVATIVE SOD CONSEILS RECH APPLIC (FR) 2003-10-15 EP claimed
US-20010056091-A1 Therapeutic use of a thienylcyclohexylamine derivative SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) 2001-12-27 US claimed
US-6207685-B1 INHIBITING EFFECTS OF EXOGENOUS NEUROTOXIC OR NEUROTOXINIC PRODUCTS IN WARM-BLOODED ANIMALS BY ADMINISTERING 2-METHYL-1-(1-PIPERIDINYL)-1-(2-THIENYL)-CYCLOHEXANE IN PURE RACEMIC, DIASTEREOISOMERIC OR ENANTIOMERIC FORM SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2001-03-27 US claimed
US-5972952-A THERAPY FOR STROKE, NERVOUS SYSTEM DISORDERS, ALZHEIMER'SDISEASE LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1999-10-26 US claimed
CN-117235898-A Ship model building method and device, electronic equipment and readable storage medium 上海外高桥造船有限公司 2023-12-15 CN disclosed
WO-2022140636-A1 GACYCLIDINE OTIC FORMULATIONS AND USES THEREOF OTONOMY, INC. (US) 2022-06-30 WO disclosed
US-20120208848-A1 GACYCLIDINE FORMULATIONS NEUROSYSTEC CORPORATION (US) 2012-08-16 US disclosed
US-20110136870-A1 GACYCLIDINE FORMULATIONS NEUROSYSTEC CORPORATION (US) 2011-06-09 US disclosed
US-6207685-B1 INHIBITING EFFECTS OF EXOGENOUS NEUROTOXIC OR NEUROTOXINIC PRODUCTS IN WARM-BLOODED ANIMALS BY ADMINISTERING 2-METHYL-1-(1-PIPERIDINYL)-1-(2-THIENYL)-CYCLOHEXANE IN PURE RACEMIC, DIASTEREOISOMERIC OR ENANTIOMERIC FORM SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2001-03-27 US disclosed
US-6107495-A REACTING SPECIFIED 1-(2- OR 3-THIENYL) CYCLOHEXANES WITH A 1,5-DIHALOPENTANE TO FORM CYCLIC (THIENYLCYCLOHEXYL)AMINES SUCH AS 2-ALKYL-(3-THIENYL)CYCLOHEXYL PIPERIDINE; USE AS INTERMEDIATES TO RADIOACTIVE LABELLED MOLECULES SOCIETE D'EXPANSION SCIENTIFIQUE EXPANSIA (FR) 2000-08-22 US disclosed
US-5972952-A THERAPY FOR STROKE, NERVOUS SYSTEM DISORDERS, ALZHEIMER'SDISEASE LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1999-10-26 US disclosed
EP-0915867-A1 THIENYLCYCLOHEXANE DERIVATIVES FOR THIENYLCYCLOHEXYL SYNTHESIS Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) 1999-05-19 EP disclosed
WO-1998003498-A1 THIENYLCYCLOHEXANE DERIVATIVES FOR THIENYLCYCLOHEXYL SYNTHESIS SOCIETE D'EXPANSION SCIENTIFIQUE EXPANSIA (FR) 1998-01-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110136870-A1 GACYCLIDINE FORMULATIONS DCTD, TYMP, TYMS SIGMAR1 4210/4885PRCP 1573/4885MEN1 817/4885
US-20120208848-A1 GACYCLIDINE FORMULATIONS DCTD, TYMP, TYMS SIGMAR1 4210/4885PRCP 1573/4885MEN1 817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.