Alpha-Ketoglutaric Acid

Alpha-Ketoglutaric Acid

SCHEMBL393522

NCCC[C@H](N)C(=O)O.O=C(O)CCC(=O)C(=O)O

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSR P00390 2/20 0.60
CYP1A2 P05177 2/20 0.53
GRM8 O00222 2/20 0.53
GRM6 O15303 2/20 0.53
GRM7 Q14831 2/20 0.53
GRM4 Q14833 2/20 0.53
GRIN2D O15399 1/20 0.53
GRIN3B O60391 1/20 0.53
GRIK1 P39086 1/20 0.53
GRM5 P41594 1/20 0.53
GRIA1 P42261 1/20 0.53
GRIA2 P42262 1/20 0.53
GRIA3 P42263 1/20 0.53
SLC1A3 P43003 1/20 0.53
SLC1A2 P43004 1/20 0.53
SLC1A1 P43005 1/20 0.53
GRIA4 P48058 1/20 0.53
GRIN1 Q05586 1/20 0.53
GRIN2A Q12879 1/20 0.53
GRIK2 Q13002 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alpha-Ketoglutaric Acid SCHEMBL393521 1.00 GSR (0.60) GSRCYP1A2GRM8GRM6GRM7
Glutamic Acid SCHEMBL4234847 0.97 GSR (0.60) GSRCYP1A2GRM8GRM6GRM7
D-Glutamate SCHEMBL4234844 0.97 GSR (0.60) GSRCYP1A2GRM8GRM6GRM7
Lysine SCHEMBL3457784 0.95 GSR (0.69) GSRCYP1A2GRM8GRM6GRM7
Lysine SCHEMBL1442876 0.95 GSR (0.69) GSRCYP1A2GRM8GRM6GRM7
Glutamic Acid SCHEMBL15565683 0.94 GSR (0.56) GSRCYP1A2GRM8GRM6GRM7
Alpha-Ketoglutaric Acid SCHEMBL20857029 0.91 GSR (0.59) GSRCYP1A2GRM8GRM6GRM7
Ornithine SCHEMBL3780210 0.91 GSR (0.72) GSRCYP1A2GRM8GRM6GRM7
Ornithine Aketoglutarate SCHEMBL28844313 0.91 GSR (0.72) GSRCYP1A2GRM8GRM6GRM7
(S)-2-Aminoadipic Acid SCHEMBL1470353 0.89 GSR (0.57) GSRCYP1A2GRM8GRM6GRM7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 283 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116019801-B Amino acid composition for promoting secretion of endogenous growth hormone 再造再生健康科技(杭州)有限公司 2024-04-05 CN claimed
CN-116019801-A Amino acid composition for promoting secretion of endogenous growth hormone 再造再生健康科技(杭州)有限公司 2023-04-28 CN claimed
US-11504351-B2 Methods for restoring stem cell pools and reducing epigenetic age DISCHLER LOUIS (US) 2022-11-22 US claimed
EP-4081205-A1 COMPOSITIONS AND METHODS INVOLVING AMINO ACIDS FOR THE TREATMENT OF FAT INFILTRATIONS IN MUSCLE Axcella Health Inc. (US) 2022-11-02 EP claimed
US-20220273690-A1 Edible Formulations Based on Active Ingredients and Arginine GRAAL S R L (IT) 2022-09-01 US claimed
CN-217247316-U Ornithine ketoglutaric acid is synthetic with micropore filter 南通紫琅生物医药科技有限公司 2022-08-23 CN claimed
US-20220257558-A1 METHODS FOR RESTORING STEM CELL POOLS AND REDUCING EPIGENETIC AGE DISCHLER LOUIS (US) 2022-08-18 US claimed
EP-4021508-A1 FORMULATIONS COMPRISING ARGININE AND/OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN ACID ACTIVE INGREDIENT WITH A PKA OF 1 -5 Graal S.r.l. (IT) 2022-07-06 EP claimed
US-11344528-B2 Compositions for promoting the endogenous self-renewal of stem cells DISCHLER LOUIS (US) 2022-05-31 US claimed
CN-216500049-U Centrifugal machine for synthesizing ornithine ketoglutaric acid 南通紫琅生物医药科技有限公司 2022-05-13 CN claimed
US-8168241-B2 For enhancing physical performance of human, foods RELIV INTERNATIONAL, INC. (US) 2012-05-01 US claimed
WO-2012024291-A1 METHODS FOR PREPARING A FERMENTED GINSENG CONCENTRATE OR POWDER ILHWA CO. LTD (US) 2012-02-23 WO claimed
US-20120045428-A1 METHODS FOR PREPARING A FERMENTED GINSENG CONCENTRATE OR POWDER IL HWA CO., LTD. (US) 2012-02-23 US claimed
EP-2020999-A1 COMPOSITIONS COMPRISING ALPHA-KETOGLUTARATE AND THEIR USE FOR MODULATING MUSCLE PERFORMANCE SGP & SONS AB (SE) 2009-02-11 EP claimed
WO-2007122190-A1 COMPOSITIONS COMPRISING ALPHA-KETOGLUTARATE AND THEIR USE FOR MODULATING MUSCLE PERFORMANCE SGP & SONS AB (SE) 2007-11-01 WO claimed
EP-1737482-A2 COMPOSITIONS AND METHODS FOR TREATING DISEASES Lumen Therapeutics, LLC (US) 2007-01-03 EP claimed
WO-2005084301-A2 COMPOSITIONS AND METHODS FOR TREATING DISEASES LUMEN THERAPEUTICS, LLC (US) 2005-09-15 WO claimed
US-20050090545-A1 Nitric oxide topical technology LEITMAN LORN (US) 2005-04-28 US claimed
US-20010041187-A1 PERFORMANCE-ENHANCING DIETARY SUPPLEMENT RELIV' INTERNATIONAL, INC. 2001-11-15 US claimed
US-5817329-A CONTAINING ACETYL-L-CARNITINE HSBC BANK CANADA (CA) 1998-10-06 US claimed