Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138349 | 0.85 | TP53 (0.53) | KMT2ATSHRKDM4ESMN1; SMN2LMNA | |
| SCHEMBL7848585 | 0.82 | KMT2A (0.50) | KMT2ATSHRGPBAR1CYSLTR1KDM4E | |
| 1,3-Dipropoxybenzene SCHEMBL73716 | 0.80 | KMT2A (0.63) | KMT2ATSHRGPBAR1CYSLTR1KDM4E | |
| SCHEMBL9457403 | 0.79 | MAOB (0.36) | TSHRLMNATP53CYP3A4 | |
| SCHEMBL928621 | 0.77 | LTA4H (0.50) | KMT2ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL899943 | 0.77 | ALDH1A1 (0.42) | KMT2ATSHRKDM4E | |
| SCHEMBL5251988 | 0.76 | KMT2A (0.47) | KMT2ATSHRGPBAR1CYSLTR1KDM4E | |
| SCHEMBL874093 | 0.76 | KMT2A (0.54) | KMT2ATSHRGPBAR1CYSLTR1KDM4E | |
| SCHEMBL7614389 | 0.76 | KMT2A (0.54) | KMT2ATSHRGPBAR1CYSLTR1KDM4E | |
| SCHEMBL1438757 | 0.76 | MAOB (0.56) | KMT2AKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264036-A1 | Amino-imidazolones for the inhibition of beta-secretase | Wyeth LLC (Formerly Known As Wyeth) (US) | 2010-12-22 | — | — | EP | disclosed |
| US-20090253716-A1 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-10-08 | — | — | US | disclosed |
| US-7563796-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2009-07-21 | — | — | US | disclosed |
| EP-1836208-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | Wyeth Incoporated (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20060160828-A1 | Amino-imidazolones for the inhibition of beta-secretase | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
| WO-2006076284-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | WYETH (US) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160828-A1 | Amino-imidazolones for the inhibition of beta-secretase | BACE1, BACE2, APP | KMT2A 3367/4885TSHR 4825/4885GPBAR1 2849/4885 |
| US-20090253716-A1 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE | BACE1, BACE2, APP | KMT2A 3367/4885TSHR 4825/4885GPBAR1 2849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.