Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453561 | 0.74 | PARP10 (0.49) | ALDH1A1SMN1; SMN2NPC1KDM4E | |
| SCHEMBL3028292 | 0.73 | ENPP2 (0.48) | LMNAMAPTALDH1A1SMN1; SMN2HDAC1 | |
| SCHEMBL1569197 | 0.73 | LMNA (0.47) | LMNAMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL3026046 | 0.70 | LMNA (0.58) | LMNAMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL3031503 | 0.69 | PARP1 (0.54) | HPGD | |
| SCHEMBL20397388 | 0.69 | PTGDR2 (0.69) | MAPTALDH1A1SMN1; SMN2GAAPPARD | |
| SCHEMBL3031961 | 0.69 | ALOX5 (0.42) | MAPTSMN1; SMN2HDAC1NPC1KDM4E | |
| SCHEMBL3454177 | 0.69 | LCK (0.44) | — | |
| SCHEMBL3034523 | 0.69 | MAOB (0.52) | ALDH1A1HPGD | |
| SCHEMBL3035153 | 0.68 | MEN1 (0.53) | MAPTSMN1; SMN2GAAKLKB1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | claimed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |