Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | NPY2R | P49146 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3458724 | 0.89 | KMT2A (0.67) | HTTRAB9AGAAMAPTKMT2A | |
| SCHEMBL3457501 | 0.84 | HTT (0.65) | HTTRAB9AGAAALDH1A1MAPT | |
| SCHEMBL28904929 | 0.77 | CHRM2 (0.53) | HTTRAB9AGAAALDH1A1KMT2A | |
| SCHEMBL7946340 | 0.75 | RAB9A (0.58) | HTTRAB9AGAAALDH1A1MAPT | |
| SCHEMBL3411267 | 0.75 | RAB9A (0.60) | HTTRAB9AGAAALDH1A1MAPT | |
| SCHEMBL3468642 | 0.74 | HTT (0.60) | HTTRAB9AGAAALDH1A1MAPT | |
| SCHEMBL3458474 | 0.74 | KMT2A (0.70) | HTTRAB9AGAAALDH1A1MAPT | |
| SCHEMBL5113589 | 0.73 | BCHE (0.69) | HTTRAB9AALDH1A1KMT2ALMNA | |
| SCHEMBL3459033 | 0.72 | RAB9A (0.58) | HTTRAB9AGAAALDH1A1MAPT | |
| SCHEMBL5098443 | 0.72 | KMT2A (0.70) | HTTRAB9AGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010435-A2 | FUSED OXAZOLE AND THIAZOLE DERIVATIVES AS TRPMS MODULATORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2010-01-28 | — | — | WO | disclosed |