Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FER | P16591 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9056372 | 0.81 | AHR (0.53) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL9056376 | 0.81 | AHR (0.53) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL16760895 | 0.74 | LRRK2 (0.62) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL1898716 | 0.74 | LRRK2 (0.62) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL1898719 | 0.74 | LRRK2 (0.62) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| Hydrochloric Acid SCHEMBL11498808 | 0.73 | LRRK2 (0.61) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL3456349 | 0.72 | NPC1 (0.55) | MAOAMAOBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL2217338 | 0.72 | NPC1 (0.55) | MAOAMAOBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL8874278 | 0.71 | MAOA (0.62) | LRRK2ACVR1MAOAMAOBPDGFRA | |
| SCHEMBL7051810 | 0.71 | MAOA (0.62) | LRRK2ACVR1MAOAMAOBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256104-A1 | Process for the preparation of alpha-aminosubstituted carboxylic acid amides | Merck Patent GmbH (DE) | 2010-12-01 | — | — | EP | disclosed |
| US-7166720-B2 | Process for the preparation of α-aminosubstituted carboxylic acid amides | MERCK PATENT GESELLSCHAFT (DE) | 2007-01-23 | — | — | US | disclosed |
| US-7053211-B2 | Process for the preparation of α-aminosubstituted carboxylic acid amides | MERCK PATENT GMBH (DE) | 2006-05-30 | — | — | US | disclosed |
| US-20040034250-A1 | Process for the preparation of alpha-aminosubstituted carboxylic acid amides | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2004-02-19 | — | — | US | disclosed |
| EP-1345908-A2 | PROCESS FOR THE PREPARATION OF ALPHA-AMINOSUBSTITUTED CARBOXYLIC ACID AMIDES | MERCK PATENT GmbH (DE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051813-A2 | PROCESS FOR THE PREPARATION OF α-AMINOSUBSTITUTED CARBOXYLIC ACID AMIDES | MERCK PATENT GMBH (DE) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034250-A1 | Process for the preparation of alpha-aminosubstituted carboxylic acid amides | ASNS, HNMT, NAAA | LRRK2 4291/4885ACVR1 1804/4885MAOA 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.